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首页> 美国政府科技报告 >Comparison of DNA Adduct Levels in Human Placenta from Polychlorinated BiphenylExposed Women and Smokers in Which CYP 1A1 Levels Are Similarly Elevated
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Comparison of DNA Adduct Levels in Human Placenta from Polychlorinated BiphenylExposed Women and Smokers in Which CYP 1A1 Levels Are Similarly Elevated

机译：来自多氯联苯暴露的女性和吸烟者的人类胎盘DNa加合物水平的比较，其中CYp 1a1水平同样升高

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Cigarette smoking is associated with high elevations in levels of both cytochromeP450 1A1 (CYP 1A1) and DNA adducts in human placenta. The identity of the smoking related adducts is not known. The DNA adducts identified in placenta of smokers could result from chemicals present in cigarette smoke, substances formed by CYP 1A1 metabolic activation of endogenous compounds, non-cigarette related exposures, or a combination of these processes. Exposure to contaminated rice oil containing large doses of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) also resulted in massive elevation of CTP 1A1 in human placenta but formation of DNA adducts from this exposure has not previously been reported. Using (32)P-postlabeling techniques that readily detect DNA adducts in placental tissue from smokers, we found no evidence of DNA adducts among specimens obtained from PCB/PCDF exposed individuals. These data suggest that CYP 1A1 induction does not induce DNA adducts detectable by this approach, and that smoking related adducts are not a consequence of CYP 1A1 induction mediated activation of endogenous compounds or xenobiotics other than cigarette smoke.

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