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首页> 美国政府科技报告 >Steroidogenic Assessment Using Ovary Culture in Cycling Rats: Effects of Bis(2-Diethylhexyl) Phthalate on Ovarian Steroid Production
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Steroidogenic Assessment Using Ovary Culture in Cycling Rats: Effects of Bis(2-Diethylhexyl) Phthalate on Ovarian Steroid Production

机译：循环大鼠卵巢培养的类固醇激素评估：邻苯二甲酸二（2-二乙基己基）酯对卵巢甾体生产的影响

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In vitro whole-ovary culture in rats was used to characterize ovarian steroidogenesis and to evaluate changes produced by in vivo exposure to bis(2-diethylhexyl) phthalate (DEHP). Steroidogenic profiles (progesterone (P4), estradiol (E2), and testosterone (T)) from minced ovary cultures were obtained in untreated immature and mature rats, and from mature rats treated with DEHP. A one-hour incubation without human chorionic gonadotropin (hCG) was used to produce a basal steroidogenic profile. Three one-hour incubations with hCG were used to produce a stimulated profile. Using a multivariate statistical analysis, a combination of basal and stimulated ovarian steroid profiles correctly identified the stage of the cycle all untreated rats. Alone, basal or stimulated ovarian steroid profiles correctly identified the stage of the cycle in more than 90% of the rats. The statistical analysis using a combination of variables (multivariate) indicated that DEHP treated rats were significantly different (P

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