• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国政府科技报告 >Respiratory Syncytial Virus Infection of Human Primary Nasal and Bronchial Epithelial Cell Cultures and Bronchoalveolar Macrophages.
【24h】

Respiratory Syncytial Virus Infection of Human Primary Nasal and Bronchial Epithelial Cell Cultures and Bronchoalveolar Macrophages.

机译：呼吸道合胞病毒感染人原发性鼻和支气管上皮细胞培养及支气管肺泡巨噬细胞。

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In adults, clinical symptoms caused by respiratory syncytial virus (RSV) are confined to the upper respiratory tract, while RSV infection in infants frequently causes bronchiolitis and pneumonia. The preferential localization of RSV infection to the upper airways may be due partially to protective immunity, but may also depend on a difference in susceptibility of epithelial cells from upper and lower airways, or on antiviral activities of bronchoalveolar macrophages (AM). In the study, the authors have compared the susceptibility of primary adult human nasal epithelium (NE), primary human bronchial epithelium (BE), a human bronchial epithelial cell line (BEAS-2B), and adult human AM, to infection with RSV. The cell cultures were infected with multiplicities of infection (moi) of 1 and 0.1. Virus release into the supernatants was assayed at days 1, 2, 4, and 7, and % of virus positive cells determined by immunofluorescence at the same timepoints. Based on study observations, the authors conclude that at least under the conditions of primary culture, both adult human NE and BE are highly susceptible to RSV infection; however, the NE release more infectious virus than BE. Although AM are infected by RSV, virus replication and spread by reinfection are restricted in these cells, suggesting that AM are probably not important in the spread of virus, and may play a protective role in RSV infection of the bronchoalveolar region of the lung.

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号