首页> 美国政府科技报告 >Pharmacokinetics of Benzoic Acid, 2-Chloro-5-(((5,6-Dihydro-2-Methyl-1,4-Oxathiin-3-YL)Carbonyl)Amino)-1- Methylethyl Ester (NSC-D615985) in Rats.

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Pharmacokinetics of Benzoic Acid, 2-Chloro-5-(((5,6-Dihydro-2-Methyl-1,4-Oxathiin-3-YL)Carbonyl)Amino)-1- Methylethyl Ester (NSC-D615985) in Rats.

机译：苯甲酸，2-氯-5 - （（（5,6-二氢-2-甲基-1,4-氧硫杂环己烷-3-YL）羰基）氨基）-1-甲基乙基酯（NsC-D615985）在大鼠体内的药代动力学。

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In the study, male Fischer 344 rats were intravenously, intraperitoneally, or orally administered NSC-D615985 which was formulated in 20 percent Liposyn II at dose levels ranging from 10 to 750 mg/kg body weight. Blood was collected for plasma drug concentration analysis at the following time-points after dosing: 2, 5, 15, 30, 60, 90, 120, and 180 minutes. For the intravenous group, plasma levels decreased from approximately 7.6 microgram/mL at 2 minutes after dosing to less than 1 microgram/mL at 15 minutes after dosing and were undetectable at lower concentrations up to 90 minutes after treatment. No detectable levels of the test article were observed in the plasma of rats at any time-point following intraperitoneal or oral treatment (100 mg/kg and 750 mg/kg, respectively).

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作者
Placke, M. E.; Tosca, P. J.;
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年度 1992
页码 1-115
总页数 115
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Pharmacokinetic; Benzoic acids; Antiviral agents; Rats; Dose-resonse relationships; Drug administration routes; Biological availability; Body weight; NSC-D615985;

机译：药代动力学;苯甲酸;抗病毒药;大鼠;剂量 - 共振关系;给药途径;生物利用度;体重; NsC-D615985;

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专利

1. Synthesis of 1-Methylethyl2-Chloro-5-(5,6-dihydro-2-methyl-1,4-oxathiin-3-Yl)carbonylamino Benzoate Analogs and Their Antiviral Activity [J] . 无中国药学（英文版） . 2000,第004期

机译：1-甲基乙基2-氯-5-（（5,6-二氢-2-甲基-1,4-氧杂嘧啶-3-Yl）羰基氨基氨基苯甲酸酯类似物的合成及其抗病毒活性
2. Synthesis of 1-Methylethyl 2-Chloro-5[[5,6-dihydro-2-methyl-1, 4- oxathiin-3-yl) carbonyl] amino] Benzoate Analogs and Their Antiviral Activity [J] . Ji Xiaoshen, Wang Yulun, Zhang Huafeng Journal of Chinese Pharmaceutical Sciences . 2000,第4期

机译：1-甲基乙基2-氯-5 [[5,6-二氢-2-甲基-1，4-氧杂嘧啶-3-基）羰基]氨基]苯甲酸酯类似物的合成及其抗病毒活性
3. In vitro and in vivo trans-esterification of 1-(2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl)-3(S)- benzyl-piperidine-3-carboxylic acid ethyl ester and the effects of ethanol on its pharmacokinetics in rats. [J] . Chen Z, Agrawal AK, Franklin RB, Pharmaceutical research . 2004,第6期

机译：1-（2（R）-（2-氨基-2-甲基丙酰氨基）-3-（1H-吲哚-3-基）丙酰基）-3（S）-苄基-哌啶-的体外和体内酯交换反应3-羧酸乙酯和乙醇对其大鼠药代动力学的影响。
4. Mathematical analysis of ~(13)CO_2-expiration curves from human breath tests using 1-~(13)C-amino acids as oral substrate [C] . V.V.A.M. Schreurs, K. Krawielitzki Joint Symposium on Energy and Protein Metabolism and Nutrition . 2003

机译：〜（13）CO_2折架曲线的数学分析使用1-（13）C - 氨基酸作为口服底物
5. Role of peptide transporter PEPT1 in the intestinal absorption and pharmacokinetics of the amino acid ester prodrug valacyclover [D] . Yang, Bei 2012

机译：肽转运蛋白PEPT1在氨基酸酯前药valacyclover的肠道吸收和药代动力学中的作用
6. Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction [O] . Marcel Holzer, Sigrid Ziegler, Bernd Kronenberger, 2008

机译：微波合成氨基酸酯取代的苯甲酰胺：人类CD81受体HCV-E2相互作用的潜在抑制剂。
7. Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction [O] . Holzer, Marcel, Ziegler, Sigrid, Kronenberger, Bernd, 2008

机译：微波合成氨基酸酯取代的苯甲酰胺：人类CD81受体HCV-E2相互作用的潜在抑制剂。
8. Final Report on the Dose Range-Finding Study of Benzoic Acid, 2-Chloro-5-(((5,6-Dihydro-2-Methyl-1,4-Oxathiin-3-YL)Carbonyl)Amino)-1- Methylethyl Ester (NSC-D615985) in Male Mice. Volume 1. [R] . Placke, M. E., Tosca, P. J. 1989

机译：关于苯甲酸，2-氯-5 - （（（5,6-二氢-2-甲基-1,4-氧硫杂环丁烷-3-YL）羰基）氨基）-1-甲基乙基的剂量范围研究的最终报告雌性小鼠中的酯类（NsC-D615985）。第1卷。

Pharmacokinetics of Benzoic Acid, 2-Chloro-5-(((5,6-Dihydro-2-Methyl-1,4-Oxathiin-3-YL)Carbonyl)Amino)-1- Methylethyl Ester (NSC-D615985) in Rats.

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