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Kinetic Model of Mammalian Cell Cultures and Fitting It to the Sp 2/0-Ag14 Culture

机译：哺乳动物细胞培养动力学模型及其与sp 2/0-ag14培养的拟合

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A mathematical and kinetic model of mammalian cell culture is developed to describe the dynamics of animal cell growth and the formations of waste products and monoclonal antibodies in suspension fed-batch and batch cultures. The models of substrates consumption and products formation are set up on the basis of the metabolic phenomenal comprehension and mass balances. The specific growth rate is described by a model similar to the two substrates and two products-inhibition Monod-type ones. The specific death rate is a function of glutamine, ammonia and lactate concentrations with the form of inverted one substrate and two by-products inhibition Monod-type equation. The model was also simplified partly by analyzing the model parameter sensitivity to the precision of the model and by taking into account the independent character of the model equations.

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作者
Zhang, X.; Visala, A.; Halme, A.;
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年度 1992
页码 1-15
总页数 15
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Cultured cells ; Kinetics ; Cell cycle ; Mathematical models ; Monoclonal antibodies ; Fermentation ; Metabolism ; Growth;

机译：培养细胞;动力学;细胞周期;数学模型;单克隆抗体;发酵;代谢;生长;

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1. Predicting industrial-scale cell culture seed trains-A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method [J] . Rodriguez Tanja Hernandez, Posch Christoph, Schmutzhard Julia, Biotechnology and Bioengineering . 2019,第11期

机译：预测工业规模的细胞培养种子列车 - 一种用于模型拟合和参数估计的贝叶斯框架，处理测量和模型参数的不确定性，使用MCMC方法应用于非线性动力学细胞培养模型
2. Dynamic metabolic network modeling of mammalian Chinese hamster ovary (CHO) cell cultures with continuous phase kinetics transitions [J] . Kastelic Miha, Kopac Drejc, Novak Uros, Biochemical Engineering Journal . 2019,第期

机译：哺乳动物中国仓鼠卵巢（CHO）细胞培养的动态代谢网络建模与连续相位动力学过渡
3. Effects of ethanol on lateral and rotational mobility of plasma membrane vesicles isolated from cultured mouse myeloma cell line Sp2/0-Ag14 [J] . Jung-Sook Kang, Chul-Min Choi, Il Yun Biochimica et biophysica acta. Biomembranes . 1996,第2期

机译：乙醇对培养的小鼠骨髓瘤细胞Sp2 / 0-Ag14细胞质膜囊泡横向和旋转运动的影响
4. PARAMETRIC IDENTIFIABILITY OF A STRUCTURED KINETIC MODEL FOR MAMMALIAN CELL CULTURES [C] . Fabio R. Sidoli, Athanasios Mantalaris, Steven P. Asprey IFAC Symposium on Modelling and Control in Biomedical Systems (including Biological Systems) . 2003

机译：哺乳动物细胞培养物结构化动力学模型的参数标识
5. Modelling batch and fed-batch mammalian cell cultures for optimizing MAb productivity. [D] . Dorka, Penny. 2007

机译：为分批和补料分批哺乳动物细胞培养建模，以优化单克隆抗体的生产率。
6. Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling [O] . Jianlin Xu, Peifeng Tang, Andrew Yongky, 2019

机译：基于短时培养和动力学建模的中国仓鼠卵巢细胞温度转移策略的系统开发
7. Predicting industrial‐scale cell culture seed trains–A Bayesian framework for model fitting and parameter estimation, dealing with uncertainty in measurements and model parameters, applied to a nonlinear kinetic cell culture model, using an MCMC method [O] . Tanja Hernández Rodríguez, Christoph Posch, Julia Schmutzhard, 2019

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8. Cellular Track Model of Biological Damage to Mammalian Cell Cultures fromGalactic Cosmic Rays [R] . Cucinotta, F. A., Katz, R., Wilson, J. W., 1991

机译：云顶宇宙线对哺乳动物细胞培养生物损伤的细胞跟踪模型

Kinetic Model of Mammalian Cell Cultures and Fitting It to the Sp 2/0-Ag14 Culture

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