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Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. AReport from ICPEMC Committee 1

机译：短期遗传毒性试验数据的组合和比较方法：前言。来自ICpEmC委员会的aReport 1

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Short-term testing methods, encompassing a wide variety of species and geneticmechanisms, have been developed to detect genetic effects produced by chemicals. The use of multiplicity of tests has created a difficult and controversial challenge in the interpretation of mixed test results. The driving principle of this report and the International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC) Committee 1 was to combine the major parameters of testing (dose, metabolic activation, sign of response, and the replication of test data) into a single score which could be pooled by entry, by test (e.g., Salmonella reverse mutation), by test class (e.g., bacterial mutation), and by family (in vitro or in vivo), into a composite score for a chemical. The system is designed: (i) to cope with redundant data, disagreement, and sporadically filled matrices; (ii) to supply statistical properties by chemical and by test; and (iii) to have features of self-learning to improve predictive performance and internal consistency for any one of several types of genetic hazard.

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Brusick, D. J.; Ashby, J.; de Serres, F. J.; Lohman, P. H. M.; Matsushima, T.;
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年度 1992
页码 1-63
总页数 63
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Mutagenicity tests; Mutagens; Comparison; Chromosome aberrations; Neoplastic celltransformation; Drosophila; DNA repair; Dose-response relationships; Statistical analysis; Reprints;

机译：致突变性试验;诱变剂;比较;染色体畸变;肿瘤细胞转化;果蝇; DNa修复;剂量 - 反应关系;统计分析;重印;

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1. SHORT-TERM BACTERIAL TESTS AS A CONVENIENT METHOD FOR SCREENING ASSESSMENT OF PHOTO- GENOTOXIC PROPERTIES OF PHARMACEUTICALS [J] . Agata Skrzypczak, rnAnita Bonislawska, rnGrzegorz Nalecz-Jawecki, Fresenius Environmental Bulletin . 2010,第2期

机译：短期细菌检测作为筛选药物遗传发光特性的便捷方法
2. Fluconazole and amphotericin B antifungal susceptibility testing by National Committee for Clinical Laboratory Standards broth macrodilution method compared with E-test and semiautomated broth microdilution test. [J] . J van Eldere, L Joosten, V Verhaeghe, Journal of Clinical Microbiology . 1996,第4期

机译：全国临床实验室标准委员会肉汤大量稀释法对氟康唑和两性霉素B的抗真菌药敏试验与E检验和半自动肉汤微量稀释试验进行了比较。
3. The interpretation of data from collaborative trials: comparing the harmonised protocol with the Analytical Methods Committee robust method [J] . Lowthian PJ., Wood R., Thompson M. The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 1998,第12期

机译：协作试验数据的解释：将统一方案与分析方法委员会的稳健方法进行比较
4. Sensor and data fusion contest: test imagery to compare and combine airborne SAR and optical sensors for mapping [C] . Hellwich, O., Reigber, Geoscience and Remote Sensing Symposium, 2002. IGARSS '02. 2002 IEEE International . 2002

机译：传感器和数据融合竞赛：测试图像以比较和组合机载SAR和光学传感器进行制图
5. Assessing, Comparing, and Combining State machine-Based Testing and Structural Testing: A Series of Experiments. [D] . Mouchawrab, Samar. 2010

机译：评估，比较和组合基于状态机的测试和结构测试：一系列实验。
6. Fluconazole and amphotericin B antifungal susceptibility testing by National Committee for Clinical Laboratory Standards broth macrodilution method compared with E-test and semiautomated broth microdilution test. [O] . J L Rodríguez-Tudela, J V Martinez-Suarez 1997

机译：全国临床实验室标准委员会肉汤大量稀释法对氟康唑和两性霉素B的抗真菌药敏试验与E检验和半自动肉汤微量稀释试验进行了比较。
7. The bacterial identification and antimicrobial susceptibility testing are usually performed manually. Recently, the number of samples has increased and the need for automatification has grown. BioMerieux has investigated Vitek2 for this purpose. HUSLAB has assigned us to compare the identification and antimicrobial results with respect to routine methods and Vitek2. Furthermore, we evaluate test reactions, ESBL (Extended Spectrum Beta-Lactamase) production and the time what it takes to get results with Vitek2. In this study, we examined a total of 183 bacterial isolates including 76 ESBL-strains, 40 nonfermenting rods, 41 fastidious bacteria and 26 fresh clinical isolates. The results of routine methods were gathered from the patient database and following this, compared to the results given by Vitek2. Vitek2 correctly identified more than 96 f the ESBL-strains and fresh clinical isolates. The results of nonfermenting rods and fastidious bacteri a were 70 oncordant with those of the routine methods. Test reaction results of Api20E were 94 nd Api20NE 70 n concordance with Vitek2 results. Approximately 80 f all Vitek2 antimicrobial results and 90 f ESBL test results were correct. Compared to earlier studies, Vitek2 performed the tests faster than the routine methods. These results suggest that Vitek2 is capable of giving rapid and accurate results. However, nonfermenting rods and fastidious bacteria should be studied further. [O] . Järveläinen Marika, Roslund Iira, Silander Maarit 2006

机译：细菌鉴定和抗菌药敏试验通常是手动进行的。最近，样品的数量增加了，并且对自动化的需求也在增长。 BioMerieux为此进行了Vitek2的研究。 HUSLAB已指派我们比较常规方法和Vitek2的鉴定和抗菌结果。此外，我们还评估了测试反应，ESBL（扩展频谱β-内酰胺酶）的产生以及使用Vitek2获得结果所需的时间。在这项研究中，我们检查了总共183个细菌分离株，包括76个ESBL菌株，40个非发酵棒，41个营养细菌和26个新鲜临床分离株。从患者数据库中收集常规方法的结果，然后将其与Vitek2给出的结果进行比较。 Vitek2正确鉴定出超过96种ESBL菌株和新鲜的临床分离株。与常规方法相比，非发酵棒和精制细菌的结果为70。 Api20E的测试反应结果与Vitek2结果一致为94nd Api20NE 70 n。所有Vitek2抗菌结果约80 f和ESBL测试结果90 f正确。与早期的研究相比，Vitek2的测试速度快于常规方法。这些结果表明Vitek2能够给出快速而准确的结果。但是，应进一步研究非发酵棒和营养细菌。
8. Assembly and Analysis of Short-Term Genotoxicity Test Data: An ICPEMC Committee 1 Working Paper. [R] . Lohman, P. H. M., Mendolsohn, M. L., Moore, D. H., 1989

机译：短期遗传毒性试验数据的汇编和分析：ICpEmC委员会1工作文件。

Method for Combining and Comparing Short-Term Genotoxicity Test Data: Preface. AReport from ICPEMC Committee 1

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