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首页> 外文OA文献 >Analysis and comparision of Transcription Factor - Target Gene databases using network analysis. - The gene regulatory network documented on the basis of experimental evidence is analysed and compared by the graph based analysis method of various resources of gene regulatory network available from various public resource database is performed.
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Analysis and comparision of Transcription Factor - Target Gene databases using network analysis. - The gene regulatory network documented on the basis of experimental evidence is analysed and compared by the graph based analysis method of various resources of gene regulatory network available from various public resource database is performed.

机译：使用网络分析对转录因子-目标基因数据库进行分析和比较。 -基于实验证据的基因调控网络进行了分析和比较，并通过基于图的分析方法对可从各种公共资源数据库中获得的基因调控网络的各种资源进行了分析。

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摘要

Gene regulatory network assembly and analysis requires high quality knowledge sources that cover functional aspect of various components of the gene regulatory machinery. Transcription factor constitutes key gene regulatory components that usually participate in large multiprotein-DNA complexes, where they guide RNA polymerase (RNAP 1, 2 and 3) activity and regulate the onset and rate of RNA synthesis. A transcription factor (a subclass of which is formed by sequence-specific DNA binding factor) is a protein that binds directly or indirectly to specific DNA regulatory sequences, thereby controlling the flow (or transcription) of genetic information from DNA to messenger RNA Transcription factors perform this function alone or more often together with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genesA defining feature of DNA binding transcription factors is that they contain one or more DNA binding domains (DBDs), which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as activators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylase s, while also playing crucial roles in gene regulation, lacking DNA-binding domains, are not classified as transcription factors. A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. Some DNA-binding domains may also include nucleic acids in their folded structure. However there are various resources - existing with information about mammalian transcription factors. One of the more reliable among them is TFcheckpoint; a database on Transcription factor with strict reference to the experimental evidence that supports both specific binding to the DNA and specific regulation of transcription. This resource provides a comprehensive and high quality knowledge source for genome scale regulatory network studies.Another is HTRIdb which is an open access database of experimentally validated interaction among human transcription factor and their target genes. HTRIdb, however is largely based on the ChIP sequence data.
机译：基因调控网络的组装和分析需要高质量的知识资源，涵盖基因调控机制各个组成部分的功能方面。转录因子构成通常参与大型多蛋白-DNA复合物的关键基因调控成分，它们在其中指导RNA聚合酶（RNAP 1、2和3）的活性并调节RNA合成的开始和速率。转录因子（其子类由序列特异性DNA结合因子形成）是一种蛋白质，其直接或间接与特定DNA调节序列结合，从而控制遗传信息从DNA到信使RNA的流动（或转录）通过促进（作为激活剂）或阻断（作为阻遏物）募集RNA聚合酶（将遗传信息从DNA转录为RNA的酶），单独或更经常与复合物中的其他蛋白质一起执行此功能特定基因的结合DNA转录因子的一个定义特征是它们包含一个或多个DNA结合域（DBD），它们附着在与其调控基因相邻的DNA特定序列上。其他蛋白质，例如激活剂，染色质重塑剂，组蛋白乙酰化酶，脱乙酰基酶，激酶和甲基化酶，尽管在基因调控中也起着关键作用，但缺乏DNA结合域，因此未归类为转录因子。 DNA结合结构域（DBD）是一个独立折叠的蛋白质结构域，包含至少一个识别双链或单链DNA的基序。 DBD可以识别特定的DNA序列（识别序列）或对DNA具有一般的亲和力。一些DNA结合结构域还可在其折叠结构中包括核酸。但是，有各种资源-存在有关哺乳动物转录因子的信息。其中最可靠的一种是TFcheckpoint。转录因子数据库，严格参考支持DNA特异性结合和转录特异性调控的实验证据。该资源为基因组规模的调控网络研究提供了全面，高质量的知识资源。另一个是HTRIdb，这是一个开放访问的数据库，该数据库通过实验验证了人类转录因子及其靶基因之间的相互作用。但是，HTRIdb主要基于ChIP序列数据。

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    Poudel Pratik Bikram;

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  • 年度 2014
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