Patient reported that during the last three years, he had sores appeared on the lips, tongue and cheeks, 2-3 times annually, with severe pain emphasized while taking food, inability to speak normally, and difficulties maintain daily oral hygiene. Clinical examination of oral mucosa showed presence of three lesions, two on buccal mucosa and one on the tongue. The aphthae laid on inflamed and edematous surface, had irregular edges, steep bloody sides and milky white covering. Wide hyperemic ring was presented around ulcerated area. The patient applied topically, NBF gingival gel three times daily after meals, prior rinsing with 12% Chlorhexidine gluconate. Initial improvements were recorded after 7 days of treatment, and after two weeks of gel application significant improvement was noted. There was withdrawal of infiltration and edema, mild epithelization of damaged epithelium with present erythematous base. The pain was moderate, but the problem of maintaining oral hygiene and nutrition was still present. The erythematous area was evidently decreased and epithelization was visibly advanced after the second week. The dimensions of the ulcers was decreased, with depth reduced two times. After the third week ulceration epithelized, but slight redness was still present. Complete withdrew happened after week four.
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