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An Investigation into Mechanical Properties and Printability of Potential Substrates for Inkjet Printing of Orodispersible Films

机译：施电胶片喷墨印刷潜在基材的力学性能和可印刷性的研究

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Inkjet printing is novel approach in drug manufacturing that enables dispensing precise volumes of ink onto substrates. Optimal substrate properties including suitable mechanical characteristic are recognized as crucial to achieve desired dosage form performance upon administration. Identification of relevant quality attributes and their quantification is subject of intensive scientific research. The aim of this work was to explore applicability of different materials as printing substrates and explore contribution of the investigated substrate properties to its printability. Substrates were characterized with regards to uniformity, porosity, disintegration time, mechanical properties and drug dissolution. Experimentally obtained values were mathematically transformed and the obtained results were presented as relevant radar charts. It was shown that structurally different substrates may be employed for orodispersible films inkjet printing. Main disadvantage of single-polymer films was low drug load, and their printability was dependent on film flexibility and mechanical strength. Structured orodispersible film templates exhibited favorable mechanical properties and drug load capacity. Wafer edible sheets were characterized with high mechanical resistance and brittleness which somewhat diminished printability, but did not hinder high drug load. Obtained results provide insight into application of different materials as printing substrates and contribute to understanding of substrate properties which can affect printability.
机译：喷墨印刷是药品制造中的新方法，使得能够将精确的墨水分配到基材上。包括合适的机械特性的最佳基质性质被认为是在给药时获得所需的剂型性能至关重要。鉴定相关质量属性及其量化是密集科学研究的主题。这项工作的目的是探讨不同材料作为印刷基材的适用性，并探讨所研究的基材特性对其印刷性的贡献。在均匀性，孔隙率，崩解时间，机械性能和药物溶解方面表征基质。在数学上转化的实验获得的值，并将结果呈现为相关雷达图表。结果表明，结构不同的基材可用于奥多到的薄膜喷墨印刷。单聚合物薄膜的主要缺点是药物负荷低，其可印刷性取决于膜柔性和机械强度。结构化的Orodispersible薄膜模板表现出良好的机械性能和药物负荷能力。晶片可食用板材的特征在于高机械性和脆性，稍微减少可印刷性，但没有阻碍高药物载荷。获得的结果提供了洞察不同材料作为印刷基材的应用，并有助于理解可以影响可印刷性的基材性质。

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