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Gut microbiota and metabolic marker alteration following dietary isoflavone‐photoperiod interaction

机译：肠道微生物肿瘤和代谢标志物改变后膳食异黄酮 - 光周相互作用

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Abstract Introduction The interaction between isoflavones and the gut microbiota has been highlighted as a potential regulator of obesity and diabetes. In this study, we examined the interaction between isoflavones and a shortened activity photoperiod on the gut microbiome. Methods Male mice were exposed to a diet containing no isoflavones (NIF) or a regular diet (RD) containing the usual isoflavones level found in a standard vivarium chow. These groups were further divided into regular (12L:12D) or short active (16L:8D) photoperiod, which mimics seasonal changes observed at high latitudes. White adipose tissue and genes involved in lipid metabolism and adipogenesis processes were analysed. Bacterial genomic DNA was isolated from fecal boli, and 16S ribosomal RNA sequencing was performed. Results NIF diet increased body weight and adipocyte size when compared to mice on RD. The lack of isoflavones and photoperiod alteration also caused dysregulation of lipoprotein lipase (Lpl), glucose transporter type 4 (Glut‐4) and peroxisome proliferator‐activated receptor gamma (Pparg) genes. Using 16S ribosomal RNA sequencing, we found that mice fed the NIF diet had a greater proportion of Firmicutes than Bacteroidetes when compared to animals on the RD. These alterations were accompanied by changes in the endocrine profile, with lower thyroid‐stimulating hormone levels in the NIF group compared to the RD. Interestingly, the NIF group displayed increased locomotion as compared to the RD group. Conclusion Together, these data show an interaction between the gut bacterial communities, photoperiod length and isoflavone compounds, which may be essential for understanding and improving metabolic health.
机译：摘要引言异黄酮与肠道微生物瘤之间的相互作用被突出显示为肥胖和糖尿病的潜在调节因子。在这项研究中，我们研究了肠道微生物组上的异黄酮与缩短活性光周期之间的相互作用。方法将雄性小鼠暴露于含有不含异黄酮（NIF）的饮食或含有常规异黄酮水平的常规饮食（RD），其在标准的Vivarium Chow中发现。这些基团进一步分为规则（12L：12D）或短的活性（16L：8D）光周期，其在高纬度地区观察到观察到的季节性变化。分析了参与脂质代谢和脂肪发生过程的白色脂肪组织和基因。从粪便伯利中分离细菌基因组DNA，并进行16S核糖体RNA测序。结果与RD小鼠相比，NIF饮食增加了体重和脂肪细胞尺寸。缺乏异黄酮和光周期改变也引起了脂蛋白脂肪酶（LPL）的厌氧量，葡萄糖转运蛋白型（凝固件4）和过氧化物体增殖物激活受体γ（PPARG）基因。使用16S核糖体RNA测序，我们发现，与RD上的动物相比，喂养NIF饮食的小鼠比菌丝更大比例。这些改变伴随着内分泌概况的变化，与RD相比，NIF组中的甲状腺刺激激素水平降低。有趣的是，与RD组相比，NIF组显示了增加的运动量。结论在一起，这些数据显示肠道细菌群落，光周期长度和异黄酮化合物之间的相互作用，这对于理解和改善代谢健康至关重要。

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