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Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model

机译：兔盘损伤模型中T1ρ和T2磁共振成像评价腰椎间盘变性

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Study DesignAn in vivo histologic and magnetic resonance imaging (MRI) study of lumbar intervertebral disc (IVD) degeneration was conducted.PurposeTo clarify the sensitivity and efficacy of T1ρ/T2 mapping for IVD degeneration, the correlation between T1ρ/T2 mapping and degenerative grades and histological findings in the lumbar IVD were investigated.Overview of LiteratureThe early signs of IVD degeneration are proteoglycan loss, dehydration, and collagen degradation. Recently, several quantitative MRI techniques have been developed; T2 mapping can be used to evaluate hydration and collagen fiber integrity within cartilaginous tissue, and T1ρ mapping can be used to evaluate hydration and proteoglycan content.MethodsUsing New Zealand White rabbits, annular punctures of the IVD were made 10 times at L2/3, 5 times at L3/4, and one time at L4/5 using an 18-gauge needle (n=6) or a 21-gauge needle (n=6). At 4 and 8 weeks post-surgery, MRI was performed including T1ρ and T2 mapping. The degree of IVD degeneration was macroscopically assessed using the Thompson grading system. All specimens were cut for hematoxylin and eosin, safranin-O, and toluidine blue staining.ResultsDisc degeneration became more severe as the number of punctures increased and when the larger needle was used. T1ρ and T2 values were significantly different between grade 1 and grade 3 IVDs, grade 1 and grade 4 IVDs, grade 2 and grade 3 IVDs, and grade 2 and grade 4 IVDs (p<0.05). There was a significant difference between grade 1 and grade 2 IVDs only in terms of T1ρ values (p<0.05).ConclusionsT1ρ and T2 quantitative MRI could detect these small differences. Our results suggest that T1ρ and T2 mapping are sensitive to degenerative changes of lumbar IVDs and that T1ρ mapping can be used as a clinical tool to identify early IVD degeneration.
机译：进行体内组织学和磁共振成像（MRI）研究的研究设计腰椎间盘（IVD）退化.Purposeto阐明了T1ρ/ T2映射对IVD退化的敏感性和功效，T1ρ/ T2映射与退化等级之间的相关性研究了腰部IVD中的组织学发现。文学的观察IVD退化的早期迹象是蛋白质糖损失，脱水和胶原降解。最近，已经开发了几种定量MRI技术; T2映射可用于评估软骨组织内的水合和胶原纤维完整性，并且T1ρ的映射可用于评估水合和蛋白多糖含量。在L2 / 3，5的10次内，IVD的环形穿刺在10次下降10次。在L3 / 4的时间，使用18·仪表针（n = 6）或21尺针（n = 6），在L4 / 5处进行一次。在手术后4和8周，MRI在包括T1ρ和T2映射。使用汤普森分级系统宏观评估IVD退化程度。所有标本都被切割用于苏木诺和曙红，Safranin-o和甲苯胺蓝染色。由于使用的刺破次数和使用较大针头时，变得更加严重。 T1ρ和T2值在1级和3级IVDS，1级和4级，4级，2级和3级IVDS之间有显着差异，以及2级和2级和2级和4级IVD（P <0.05）。 1年级和2年级IVDS只有在T1ρ值之间存在显着差异（P <0.05）.Conclusionst1ρ和T2定量MRI可以检测到这些小差异。我们的研究结果表明，T1ρ和T2映射对腰部IVDS的退行性变化敏感，并且T1ρ映射可用作鉴定IVD退化的临床工具。

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