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Study on Hypoglycemic Effect of the Drug Pair of Astragalus Radix and Dioscoreae Rhizoma in T2DM Rats by Network Pharmacology and Metabonomics

机译：网络药理学与代谢综合学毒品对黄芪大鼠黄芪和二透视性质的降血糖作用研究

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Type 2 diabetes mellitus (T2DM) is a metabolic disease accompanied by a series of diseases such as diabetic nephropathy. The drug pair (HS) of Astragalus Radix (HQ) and Dioscoreae Rhizoma (SY) was designed by Dr. Shi Jinmo to improve the treatment of T2DM. However, the exact mechanism involved requires further clarification. In this work, 1H-NMR−based metabonomics and network pharmacology were adopted. Metabolic profiling indicated that the metabolic perturbation was reduced after HS treatment. The results found 21 biomarkers. According to the network pharmacology, we found that the regulation of T2DM was primarily associated with 18 active compounds in HS. These active compounds mainly had an effect on 135 targets. Subsequently, combining network pharmacology and metabonomics, we found four target proteins, which indicated that HS has potential hypoglycemic effects through regulating monoamine oxidases B (MAOB), acetyl-CoA carboxylase 1 (ACACA), carbonic anhydrase 2 (CA2), and catalase (CAT). In conclusion, the result showed that these four targets might be the most relevant targets for the treatment of T2DM with HS. This study clarified the mechanism of HS in the treatment of T2DM and also confirmed the feasibility of combining metabonomics and network pharmacology to study the mechanisms of traditional Chinese medicine (TCM). In the future, this approach may be a potentially powerful tool to discovery active components of traditional Chinese medicines and elucidate their mechanisms.
机译：2型糖尿病（T2DM）是一种代谢疾病，伴有一系列疾病，如糖尿病肾病。黄芪（HQ）和Dioscoreae Rhizoma（SY）的药物对（HS）是由Shi Jinmo博士设计的，改善T2DM的治疗。但是，所涉及的确切机制需要进一步澄清。在这项工作中，采用了基于1H-NMR的代谢物和网络药理学。代谢分析表明HS治疗后，代谢扰动降低。结果发现了21个生物标志物。根据网络药理学，我们发现T2DM的调节主要与HS中的18个活性化合物相关。这些活性化合物主要对135个靶标产生效果。随后，组合网络药理学和代谢物理学，我们发现了四种靶蛋白，表明HS通过调节单胺氧化酶B（MAOB），乙酰-COA羧化酶1（ACACA），碳酸酐酶2（CA2）和过氧化氢酶（）具有潜在的降血糖作用。猫）。总之，结果表明，这四个靶标可能是治疗HS治疗T2DM的最相关的靶标。本研究阐明了HS治疗T2DM的机制，并确认了组合代谢族和网络药理学的可行性，以研究中医（TCM）的机制。将来，这种方法可能是发现传统中药活性成分的潜在强大的工具，并阐明其机制。

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