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首页> 外文OA文献 >Can External Use of Chinese Herbal Medicine Prevent Cumulative Peripheral Neuropathy Induced by Oxaliplatin? A Systematic Literature Review With Meta-analysis
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Can External Use of Chinese Herbal Medicine Prevent Cumulative Peripheral Neuropathy Induced by Oxaliplatin? A Systematic Literature Review With Meta-analysis

机译：可以外用中药药物预防欧沙铂诱导的累积周围神经病变吗？荟萃分析系统文献综述

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Background. Peripheral neurotoxicity caused by oxaliplatin (OXA) chemotherapy is the main limitation preventing continuation of chemotherapy in patients with gastrointestinal cancer. The purpose of this study was to determine the efficacy of external use of Chinese herbal medicine (CHM) on the incidence of cumulative OXA-induced peripheral neurotoxicity (OIPN). Method. Scientific literature databases were searched to identify controlled clinical trials analyzing CHM in OIPN. Clinical studies that included at least 1 relevant primary outcome were analyzed by 2 independent reviewers. Meta-analysis was performed on the software RevMan 5.3. Results. 700 cancer patients of 9 studies were reported, of whom 352 received external CHM and 348 received warm water baths, conventional medicine, or no intervention as controls. Neurotoxicity incidence (Levi grade ≥ 1) was significantly decreased in CHM group, compared with no intervention ( P < .01). The incidence of cumulative neurotoxicity (Levi grade ≥2) was also significantly lower in the CHM group than in all the control groups ( P < .05), and the cumulative neurotoxicity in the CHM group was significantly reduced (Levi grade ≥ 3) in comparision with no intervention ( P .05). Conclusion . External use of CHM may be beneficial in preventing the OXA-induced cumulative neurotoxicity. However, given the low quality of the evidence, the results should be interpreted with caution.
机译：背景。 Oxaliplatin（OXA）化疗引起的外周神经毒性是防止胃肠癌患者继续延续化疗的主要限制。本研究的目的是确定中草药（CHM）对累积氧气诱导的外周神经毒性（OIPN）发生率的疗效。方法。搜索科学文献数据库鉴定oipn中CHM的受控临床试验。包括至少1个相关初级结果的临床研究分析了2名独立审稿人。在软件Revman 5.3上进行了META分析。结果。报告了700项癌症9项研究患者，其中352名接受了外部CHM，348次获得温水浴，常规药物，或无干预作为对照。在CHM组中，神经毒性发生率（Levi级≥1）显着降低，而无干预（P <.01）。 CHM组中累积神经毒性（Levi级≥2）的发生率在所有对照组中也显着降低（P <.05），CHM组中的累积神经毒性显着降低（Levi级≥3）比较无干预（p .05）。结论 。外部使用CHM可能有益于预防氧气诱导的累积神经毒性。但是，鉴于证据的低质量，结果应谨慎解释。

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