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Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only

机译：快速抽搐和慢速抽搐骨骼肌的表征，CALSECESTIN 2（CASQ2） - KNOCK OUT MICE：仅限快速抽搐肌肉的意外自适应变化

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This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2−/− mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2−/− causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2−/− mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum.

机译：本研究通过使用CASQ2 - / - 小鼠研究CALSECESTRIN 2（CASQ2）在快速抽搐和缓慢骨骼肌中的功能作用; Casq2在慢速抽搐的肌肉中始终在寿命中表达，而是仅在快速抽搐肌肉中的发育和新生儿阶段。 CASQ2 - / - 导致CALSECESTRIN 1（CASQ1）表达增加，但没有肌肉类型的功能变化。 Casq2 - / - 小鼠仅在快速抽搐肌肉中有超微结构的变化，即在肌肉网上形成五角囊和堆叠。

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作者
Giorgia Valle; Barbara Vergani; Roberta Sacchetto; Carlo Reggiani; Edith De Rosa; Lisa Maccatrozzo; Alessandra Nori; Antonello Villa; Pompeo Volpe;
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年度 2016
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正文语种 eng
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1. Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only [J] . Valle Giorgia, Vergani Barbara, Sacchetto Roberta, Journal of Muscle Research and Cell Motility . 2016,第6期

机译：快速抽搐和慢速抽搐骨骼肌的表征，CALSECESTIN 2（CASQ2） - KNOCK OUT小鼠：仅限快速抽搐肌肉的意外自适应变化
2. Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch ce:italic>via/ce:italic> Sirt1/AMPK pathway [J] . The Journal of Nutritional Biochemistry . 2018,第期

机译：精氨酸促进从快速抽搐到慢速抽搐的骨骼肌纤维型变换
3. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats. [J] . Yuanyuan Xiao, Naveen Sharma, Edward B Arias, Age. . 2013,第3期

机译：老年大鼠进行一次运动后，快肌和慢肌骨骼肌胰岛素刺激的葡萄糖摄取持续增加。
4. Mechanisms of rodent slow-twitch skeletal muscle atrophy in response to complete inactivation by spinal-isolation [C] . K. M. Baldwin, R. R. Roy, F. Haddad, Joint Engineering in Medicine and Biology Society-Biomedical Engineering Society Conference . 2002

机译：啮齿动物缓慢抽搐骨骼肌萎缩的机制响应脊柱隔离的完全失活
5. Impacts of metabolic stress-induced malnutrition and oxidative stress on biochemical changes in the slow- and fast-twitch skeletal muscles of rats [D] . He, Ying 2002

机译：代谢应激引起的营养不良和氧化应激对大鼠慢速和快速抽搐骨骼肌生化变化的影响
6. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats [O] . Yuanyuan Xiao, Naveen Sharma, Edward B. Arias, 2013

机译：老年大鼠进行一次运动后快肌和慢肌骨骼肌胰岛素刺激的葡萄糖摄取持续增加
7. The fast-twitch muscle calsequestrin isoform predominates in rabbit slow-twitch soleus muscle [O] . Fliegel Larry, Leberer Ekkehard, Green N.Michael, 1989

机译：快肌肌钙调蛋白同工型在兔慢肌比目鱼肌中占主导地位

Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only

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