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High‐frequency motor rehabilitation in amyotrophic lateral sclerosis: a randomized clinical trial

机译：肌营养侧面硬化症中的高频电机康复：随机临床试验

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Abstract Objective Exercise may be physically and psychologically important for people with ALS, especially in the earlier stages of the disease, and, as a consequence, current ALS clinical management includes individualized rehabilitation as part of multidisciplinary care because. However, while recent studies focused on which type of exercise is more indicated to ALS patients, there is no evidence at which frequency training sessions should be performed. Methods We performed an assessor blinded randomized clinical trial to investigate the superiority of two different frequencies of exercise on rate of progression in ALS. We enrolled 65 patients in two groups: intensive exercise regimen (IER, five sessions/week) versus usual exercise regimen (UER, two sessions/week). The primary aim was to assess if IER decreased disease progression, measured through Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised, with respect to UER. Secondary aims included assessment of adverse events, tracheostomy‐free survival, motor and respiratory functions, fatigue, quality of life and caregiver burden. Treatment regimen consisted for both groups of the same kind of exercise including aerobic training, endurance training, stretching or assisted active mobilization, differing for frequency of intervention. Results No significant changes in disease progression were found in patients under IER versus UER. At the end of the study, there were no significant differences between the two groups in survival, respiratory function, time to supporting procedures, and quality of life. Adverse events, fatigue, and caregiver burden were not different between the two treatment regimens. Conclusions Despite some limitations, our trial demonstrated that high‐frequency physical exercise was not superior to UER on ALSFRS‐R scores, motor and respiratory functions, survival, fatigue, and quality of life of ALS patients.
机译：摘要目标锻炼可能对患有ALS的人身体和心理上重要，特别是在疾病的早期阶段，因此，当前的ALS临床管理包括作为多学科护理的一部分的个性化康复因子。然而，虽然最近的研究侧重于哪种运动类型为ALS患者，但没有证据表明频率训练会议。方法我们进行了评估别盲思，随机临床试验，以研究两种不同频率对ALS的进展速率的优越性。我们注册了两组65名患者：强化锻炼方案（IER，五次会议/周）与常用的锻炼方案（UER，两个会议/周）。主要目的是评估IER是否减少疾病进展，通过肌营养的侧面硬化功能评级进行测量规模的，关于uer。次要目标包括评估不良事件，无气管苗条的生存，电机和呼吸功能，疲劳，生活质量和照顾者负担。治疗方案为同类运动的两组组成，包括有氧训练，耐力训练，伸展或辅助主动动员，不同于干预频率。结果IER与UER下的患者没有发现疾病进展的显着变化。在该研究结束时，两组在生存期，呼吸功能，支持程序的时间和生活质量之间没有显着差异。两种治疗方案之间的不良事件，疲劳和护理人员负担在不满。结论尽管有一些局限性，我们的审判表明，高频体育锻炼并不优于ALSFRS-R分数，电机和呼吸功能，生存，疲劳和患者生活质量。

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