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Environmental enrichment influences novelty reactivity, novelty preference, and anxiety via distinct genetic mechanisms in C57BL/6J and DBA/2J mice

机译：环境富集影响了C57BL / 6J和DBA / 2J小鼠的不同遗传机制的新型反应性，新奇偏好和焦虑

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Abstract Environmental factors such as stress drive the development of drug addiction in genetically vulnerable individuals; the genes underlying this vulnerability are unknown. One strategy for uncovering these genes is to study the impact of environmental manipulation on high-throughput phenotypes that predict drug use and addiction-like behaviors. In the present study, we assessed the viability of this approach by evaluating the relative effects of environmental enrichment and isolation housing on three high-throughput phenotypes known to predict variation on distinct aspects of intravenous drug self-administration. Prior to behavioral testing, male and female C57BL/6J and DBA/2J mice (BXD founders) were housed in enrichment or isolation for ten weeks beginning at weaning. Enrichment significantly reduced novelty reactivity; this effect was significantly more robust in C57BL/6J mice relative to DBA/2J mice. Enrichment significantly reduced novelty preference; this effect was significantly dependent on novel environment characteristics and was significantly more robust in DBA/2J mice relative to C57BL/6J mice. Enrichment significantly increased anxiety; this effect was not strain-dependent. Collectively, these data indicate that (1) environmental enrichment influences novelty reactivity, novelty preference, and anxiety via distinct genetic mechanisms in mice, and (2) the BXD panel can be used to discover the genetic and epigenetic mechanisms underlying this phenomenon.
机译：抽象的环境因素，如压力驱动遗传弱势群体吸毒成瘾的发展;这种脆弱性的基因是未知的。揭露这些基因的一种策略是研究环境操纵对预测药物使用和成瘾行为的高通量表型的影响。在本研究中，我们通过评估环境富集和分离壳体对已知的三种高通量表型的相对效果来评估这种方法的可行性，以预测静脉内药物自我给药的不同方面的变化。在行为检测之前，雄性和雌性C57BL / 6J和DBA / 2J小鼠（BXD创始人）被饲养在断奶后十周的富集或分离。富集显着降低了新颖的反应性;在相对于DBA / 2J小鼠的C57BL / 6J小鼠中，这种效果明显更稳健。富集显着减少了新颖的偏好;这种效果显着依赖于新的环境特征，并且相对于C57BL / 6J小鼠的DBA / 2J小鼠在显着更强。富集显着增加焦虑;这种效果不是应变依赖性的。总的来说，这些数据表明（1）环境富集影响了小鼠中明显的遗传机制的新型反应性，新奇偏好和焦虑，（2）BXD面板可用于发现这种现象的基因和表观遗传机制。

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