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首页> 外文OA文献 >Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation
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Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation

机译：定义血管化复合分征的慢性排斥反应 - 美国重建移植协会和国际血管化复合分征协调协调社会慢性拒绝工作组：2018年美国重建移植协会会议报告和白皮书研究目标在定义血管化复合分征中定义慢性排斥反应

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Objectives: This report summarizes a collaborative effort between the American Society of Reconstructive Transplantation and the International Society of Vascularized Composite Allotransplantation to establish what is known about chronic rejection in recipients of vascularized composite allografts, with an emphasis on upper extremity and face transplants. As a picture of chronic rejection in hand and face vascularized composite allografts emerges, the results will be applied to other types of vascularized composite allografts, such as uterine transplantation. Methods: The overall goal is to develop a definition of chronic rejection in vascularized composite allografts so that we can establish longitudinal correlates of factors such as acute rejection, immunosuppressive therapy, de novo donor-specific antibody and trauma/infection and other external factors on the development of chronic rejection. As Dr Kanitakis eloquently stated at the 2017 International Society of Vascularized Composite Allotransplantation meeting in Salzburg, “Before we can correlate causative factors of chronic rejection, we have to define what chronic rejection in VCA is.” Results: The first meeting report was presented at the sixth Biennial meeting of the American Society of Reconstructive Transplantation in November 2018. Based on collaborative efforts and descriptions of clinical cases of chronic rejection in vascularized composite allograft recipients, a working definition of chronic rejection in vascularized composite allografts with respect to overt functional decline, subclinical functional decline, histologic evidence without functional decline, and normal allograft function in the absence of histologic evidence of chronic rejection is proposed. Conclusions: It is the intent of this collaborative working group that these working definitions will help to focus ongoing research to define the incidence, risk factors and treatment regimens that will identify mechanisms of chronic rejection in vascularized composite allografts. As with all good research, our initial efforts have generated more questions than answers. We hope that this is the first of many updates.
机译：目标：本报告总结了重建移植的美国社会和带血复合异体移植的国际社会之间的合作努力，建立了被称为关于带血管移植复合受助慢性排斥反应，对上肢和面部移植的重视。如在手和脸慢性排斥的血管化图片复合同种异体移植物出现，结果将被应用到其它类型的血管化的复合移植物，如子宫移植。方法：总的目标是发展在血管化的复合移植慢性排斥的定义，以便我们可以建立的因素，如急性排斥，免疫抑制治疗，从头供体特异性抗体和创伤/感染，而在另一外部因素纵向相关因素慢性排斥的发展。作为Kanitakis博士在萨尔茨堡带血复合异体移植会议的2017年国际协会雄辩地说，“以前我们可以关联慢性排斥反应的致病因素，我们必须定义什么VCA慢性排斥反应的。”结果：第一次会议报告的基础上的合作，同时在血管化复合移植术后慢性排斥反应的临床病例说明在2018年十一月在重建移植的美国社会的第六次双年展会议上提出，在慢性排斥反应的工作定义血管化相对于复合材料移植到明显的功能衰退，亚临床功能衰退，无功能下降组织学证据，和正常移植肾功能在没有慢性排斥反应的组织学证据提出。结论：这是意图这一合作工作组，这些工作定义，将有助于集中正在进行的研究，以确定发生率，危险因素和治疗方案，将确定在带血管移植复合慢性排斥反应的机制。如同所有的很好的研究，我们最初的努力已经产生的问题多于答案。我们希望，这是第一个许多更新的。

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