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首页> 外文OA文献 >Risk of Peptic Ulcer Bleeding Associated with Helicobacter pylori Infection, Nonsteroidal Anti-inflammatory Drugs, and Low-dose Aspirin Therapy in Peptic Ulcer Disease: A Case-control Study
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Risk of Peptic Ulcer Bleeding Associated with Helicobacter pylori Infection, Nonsteroidal Anti-inflammatory Drugs, and Low-dose Aspirin Therapy in Peptic Ulcer Disease: A Case-control Study

机译：与幽门螺杆菌感染，非甾体抗炎药和低剂量阿司匹林治疗有关幽门螺杆菌感染，患者溃疡病的危险风险：病例对照研究

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Background/Aims The association between Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin therapy as a risk factor for peptic ulcer bleeding (PUB) remains unclear. This study investigated the risk of PUB associated with H. pylori infection and NSAID or low-dose aspirin therapy in patients with PUD. Materials and Methods This case-control study investigated 340 patients with PUB between 2012 and 2016. The control group comprised age and sex-matched patients with endoscopically documented non-bleeding ulcers. Using logistic regression analysis, the adjusted odds ratio (AOR) was calculated for the risk of PUB. Results Of the patients investigated, 57.9% in the study group and Results Of the patients investigated, 57.9% in the study group and 51.8% in the control group were diagnosed with H. pylori infection (P=0.106). Logistic regression analysis showed synergistic interaction between H. pylori infection and low-dose aspirin therapy. Multivariate analysis showed that low-dose aspirin (AOR 3.92, P=0.001), NSAIDs (AOR 2.98, P=0.001), warfarin (AOR 14.57, P=0.011), gastric ulcer (compared with duodenal ulcer) (AOR 1.65, P=0.01), and smoking (AOR 1.97, P=0.004) increased the risk of PUB compared with the risk of PUD.Conclusions: Both NSAIDs and aspirin are independent risk factors for bleeding in patients with PUD. Additionally, low-dose aspirin therapy concomitant with H. pylori infection produced a synergistic effect. Therefore, H. pylori eradication may be crucial in aspirin users. Moreover, a proton pump inhibitor should be prescribed in patients with a history of bleeding ulcers who need long-term NSAID treatment.
机译：背景/瞄准幽门螺杆菌感染和非甾体抗炎药（NSAID）或低剂量阿司匹林治疗作为消化性溃疡出血（PUB）的危险因素的关联仍然不清楚。本研究调查了与PYLIN感染和NSAID或低剂量阿司匹林治疗PUD患者的酒吧的风险。材料和方法本案例对照研究调查了2012年和2016年间有340例酒吧患者。对照组包括年龄和性别匹配患者的内窥镜记录的非流血溃疡。使用Logistic回归分析，计算调整后的赔率比（AOR）以实现酒吧的风险。研究患者的结果，研究组的57.9％和研究组的结果57.9％，对照组中的51.8％被诊断为H. Pylori感染（P = 0.106）。 Logistic回归分析显示H.幽门螺杆菌感染与低剂量阿司匹林治疗之间的协同相互作用。多变量分析表明，低剂量阿司匹林（AOR 3.92，P = 0.001），NSAIDS（AOR 2.98，P = 0.001），Warfarin（AOR 14.57，P = 0.011），胃溃疡（与十二指肠溃疡相比）（AOR 1.65，P = 0.01），吸烟（AOR 1.97，P = 0.004）与PUD的风险增加了PUB的风险：结论：NSAIDs和阿司匹林是患者患者出血的独立危险因素。此外，低剂量阿司匹林治疗伴随着H.幽门螺杆菌感染产生了协同作用。因此，H.幽门螺杆菌根除可能在阿司匹林用户至关重要。此外，应在有长期NSAID治疗的出血溃疡历史中进行质子泵抑制剂。

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