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首页> 外文OA文献 >Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial
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Comparison of Ketamine-Propofol and Ketamine-Thiopental on Bispectral Index Values during Monitored Anesthesia Care (MAC) in Minor Traumatic Orthopedic Surgery; A Randomized, Double-Blind, Clinical Trial

机译：在微孔骨科手术中监测麻醉护理（MAC）中氯胺酮 - 异丙酚和氯胺酮 - 硫酮酮酮的比较;随机，双盲，临床试验

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Objective: To compare the effects of ketamine-propofol and ketamine-thiopental on bispectral index values during monitored anesthesia care in minor orthopedic surgeries.Methods: This randomized double-blind clinical trial was performed on 90 patients undergoing minor orthopedic surgeries. Participants were randomly allocated to either groups of propofol or thiopental. Bispectral index (BIS), non-invasive arterial blood pressure, SpO2, and electrocardiogram were monitored every 5 minutes. Patients in propofol group received a bolus dose of 0.5 mg/kg ketamine, plus 0.5 mg/kg propofol. In thiopental group, patients received a bolus dose of 0.5 mg/kg ketamine, plus 50-75 mg thiopental. After the surgery, recovery duration, patients’ pain score (VAS) and any intra-operative recall or awareness were recorded. Statistical analysis was performed using SPSS version 19.0Results: BIS was lower in ketamin-propofol group (p< 0.001). Mean arterial blood pressure, heart rate and O2 saturation showed a significant difference between two groups (p< 0.001), which were lower in ketamin–propofol group. VAS score was higher in ketamin-thiopental group (p< 0.001). Both groups were similar in intra-operative recall/awareness.Conclusion: Ketamine-propofol combination deliver a better control over monitored anesthesia during surgery, providing lower BIS, higher O2 saturation and lower heart rate and arterial blood pressure in patients undergoing minor traumatic orthopedic surgeries.Clinical trial registration: IRCT6N 2016032320258
机译：在被接受未成年人矫治手术90例患者进行的这项随机，双盲临床试验：目的：监控麻醉护理过程中轻微骨科surgeries.Methods比较氯胺酮，丙泊酚和氯胺酮硫喷妥钠对脑电双频指数值的影响。参与者被随机分配到异丙酚或硫喷妥钠的任何群体。双频谱指数（BIS），非侵入式动脉血压，血氧饱和度，和心电图，每5分钟进行了监测。在异丙酚组患者接受的0.5毫克/千克氯胺酮，加0.5mg / kg的丙泊酚单次剂量。在硫喷妥钠组中，患者接受0.5mg / kg的氯胺酮的单次剂量，加50-75毫克硫喷妥钠。手术后，恢复持续时间后，患者的疼痛评分（VAS）和任何术中回忆或认知的记录。使用SPSS版本19.0Results进行统计分析：BIS在氯胺酮 - 丙泊酚组（p <0.001）较低。平均动脉血压，心脏速率和O 2饱和度显示两个组（P <0.001），这在氯胺酮 - 丙泊酚组明显降低之间的显著差异。 VAS评分在氯胺酮 - 硫喷妥钠组（p <0.001）更高。两组患者在术中回忆/ awareness.Conclusion类似：氯胺酮异丙酚组合在手术期间在监控麻醉提供更好的控制，提供较低的BIS，较高的氧饱和度和较低的心脏速率和血压在经历轻微创伤骨科手术患者。临床试验注册：IRCT6N 2016032320258

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