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Research hotspots and trends of bone defects based on Web of Science: a bibliometric analysis

机译：基于科学网的研究热点及骨缺陷趋势：致力测量分析

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Abstract Background Bone defects can be seen everywhere in the clinic, but it is still a challenge for clinicians. Bibliometrics tool CiteSpace is based on the principle of “co-citation analysis theory” to reveal new technologies, hotspots, and trends in the medical field. In this study, CiteSpace was used to perform co-citation analysis on authors, countries (regions) and institutions, journals and cited journals, authors and cited literature, as well as keywords to reveal leaders, cooperative institutions, and research hotspots of bone defects and predict development trends. Method Data related to bone defect from 1994 to 2019 were retrieved from the Web of Science core collection; then, we use Excel to construct an exponential function to predict the number of annual publications; conduct a descriptive analysis on the top 10 journals with the largest number of publications; and perform co-citation analysis on authors, countries (regions) and institutions, journals and cited journals, authors and cited reference, and keywords using CiteSpace V5.5 and use the Burst Detection Algorithm to perform analysis on the countries (regions) and institutions and keywords, as well as cluster the keywords using log-likelihood ratio. Results A total of 5193 studies were retrieved, and the number of annual publications of bone defects showed an exponential function Y = 1×10− 70e0.0829x (R 2 = 0.9778). The high-yield author was Choi Seong-Ho at Yonsei University in South Korea. The high-yielding countries were the USA and Germany, and the high-yielding institutions were the Sao Paulo University and China and the Chinese Academy of Sciences which were the emerging research countries and institutions. The research results were mainly published in the fields of dentistry, bone, and metabolism. Among them, the Journal of Dental Research and Journal of Bone and Mineral Research were high-quality journals that report bone defect research, but the most cited journal was the Clinical Orthopaedics and Related Research. Hot keywords were regeneration, repair, in vitro, bone regeneration, reconstruction, and graft. The keywords that were strongly cited in 2010–2019 were transportation, osteogenic differentiation, proliferation, and biomaterials. After 2018, proliferation, osteogenic differentiation, stromal cells, transmission, and mechanical properties have become new vocabulary. The drug delivery, vascularization, osteogenic differentiation and biomaterial properties of bone defects were expected to be further studied. Conclusion The application of CiteSpace can reveal the leaders, cooperating institutions and research hotspots of bone defects and provide references for new technologies and further research directions.
机译：摘要背景骨缺损随处可见的诊所，但它仍然是临床医生是一个挑战。文献计量工具CiteSpace是基于“共引分析理论”的原则，在医学领域显示新技术，热点和趋势。在这项研究中，CiteSpace是用来对作者，国家（地区）和机构，期刊共引分析和被引期刊，作者和引用的文献，以及关键字揭示领导，合作机构和骨缺损的研究热点并预测发展趋势。方法数据相关的骨缺损1994年至2019年从科学核心种质的网页被检索;然后，我们使用Excel来构造一个指数函数预测年度出版物的数量;开展的前10名期刊，出版物数量最多的一个描述性分析;并执行对作者，国家（地区）和机构，期刊共引分析和被引期刊，作者和引用的参考文献和关键字中使用CiteSpace V5.5，并使用突发检测算法的国家（地区）和机构进行分析和关键字，以及集群中使用对数似然比的关键字。结果共5193个研究，检索，和骨缺损的年度出版物的数量呈指数函数Y = 1×10- 70e0.0829x（R 2 = 0.9778）。高产的作者是崔晟浩在韩国的延世大学。高收益的国家分别是美国和德国，以及高收益的机构是圣保罗大学和中国以及中国社科院的科学内容是新兴研究的国家和机构。这一研究成果已发表主要牙科，骨和代谢的领域。其中，牙科研究杂志和骨与矿物质研究的是高品质的杂志上报告骨缺损的研究，但被引用最多的期刊是临床骨科及相关研究。热关键字是再生，修复，体外培养，骨再生，重建，和移植物。那强烈的2010-2019引用的关键字是交通，成骨细胞分化，增殖和生物材料。之后2018，增殖，成骨分化，基质细胞，传输，和机械性能已成为新的词汇。药物递送，血管形成，成骨细胞分化和骨缺损的生物材料性质预期待进一步研究。结论CiteSpace的应用可以揭示领导，合作机构和骨缺损的研究热点，并提供了新的技术和进一步研究的方向引用。

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