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A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur

机译：一种评价大鼠股骨远端松质骨力学性能的新方法

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摘要

The mechanical properties of the cancellous bone in the laboratory rat animalmodel are of great interest to the research community for the evaluation of treatments forosteoporosis. Cancellous bone responds rapidly and dramatically to disuse, variouspathologies, nutritional deficiencies, and hormonal deficiencies and hence is often aprimary focus in animal studies. Previous methods for evaluating the mechanicalproperties of cancellous bone in rat test specimens included both cortical and cancellousbone. This thesis introduces a new method to core cancellous specimens using adiamond wire saw in concert with specially designed fixtures. This method has beentermed Isolated Cancellous Coring (ICC). The location and the geometry of the coredspecimens were determined based on uCT analysis. The isolated cancellous specimenswere subjected to uni-axial compression testing to evaluate the mechanical properties.Furthermore, the new method is evaluated by directly applying it to a study investigatingthe effects of estrogen replacement therapy in post-menopausal osteoporosis assimulated by the ovariectomized rat model.The results show that the ICC method can be applied to bone specimens with alarge range in density and micro-architecture parameters. The compression testing of theisolated cancellous specimens provides a sensitive indicator of the effects ofosteoporosis and treatment on the mechanical properties of the cancellous bone in thedistal rat femur. Also, the results indicate a possible discordant relationship betweenbone mineral density and bone strength with respect to estrogen treatment. Power law regressions show that approximately 50% of the variation in ultimate strength can beaccounted for with bone mineral density and the percent of bone volume per totalvolume.
机译：实验室大鼠动物模型中松质骨的机械特性引起研究界对骨质疏松症治疗评估的兴趣。松质骨对废弃，各种病理，营养缺乏和荷尔蒙缺乏反应迅速而显着，因此通常是动物研究的主要重点。评估大鼠试样中松质骨力学性能的先前方法包括皮质骨和松质骨。本文介绍了一种使用金刚石线锯结合专门设计的夹具对松质标本取芯的新方法。这种方法被称为隔离式松散取心（ICC）。根据uCT分析确定核心样品的位置和几何形状。对分离出的松质标本进行单轴压缩试验以评估其力学性能。此外，将该新方法直接应用于研究雌激素替代疗法在卵巢切除大鼠模型模拟的绝经后骨质疏松症中的作用的研究中。结果表明，ICC方法可应用于密度和微结构参数范围较大的骨标本。分离的松质标本的压缩测试提供了骨质疏松和治疗对远端大鼠股骨松质骨力学性能影响的灵敏指标。而且，结果表明就雌激素治疗而言，骨矿物质密度与骨强度之间可能存在不一致的关系。幂律回归表明，最终强度变化的大约50％可以用骨矿物质密度和每总体积的骨体积百分比来解释。

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    Lucas Matthew W.;

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  • 年度 2010
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