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首页> 外文OA文献 >Interindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25-3T studied in an in vitro gut model
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Interindividual differences in response to treatment with butyrate-producing Butyricicoccus pullicaecorum 25-3T studied in an in vitro gut model

机译：在体外肠道模型中研究了生产丁酸盐的Buticicoccus pullicaecorum 25-3T对治疗的个体差异

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摘要

Butyrate-producing bacteria are promising probiotic candidates to target microbial dysbiosis in gastrointestinal disorders like Inflammatory Bowel Diseases. Butyricicoccus pullicaecorum 25-3(T), a butyrate-producing clostridial cluster IV strain, is such a candidate. Little is known about its abundance in the colon microbiota and its butyrogenic properties. We used the M-SHIME(®), an in vitro simulator for the human intestinal microbial ecosystem, to study the effect of supplementing a single dose of B. pullicaecorum 25-3(T) on lumen- and mucus-associated microbiota of eight individuals. B. pullicaecorum was more abundant in mucus-associated microbiota compared with lumen microbiota. Supplementation with a single dose of B. pullicaecorum 25-3(T) resulted in a temporary increase in B. pullicaecorum bacteria in lumen compartment of all individuals. In two cases, the responders, an increased butyrate production was observed as compared with the control. 16S rRNA gene amplicon sequencing revealed the microbiota of responders to be different as compared to non-responder microbiota. We can conclude that B. pullicaecorum 25-3(T) is a mucus-associated bacterium whose potency to stimulate butyrate production is characterized by a large interindividual variability in terms of composition of the receiving microbial community.
机译：产生丁酸盐的细菌是有希望的益生菌候选物，其针对胃肠道疾病如炎症性肠病中的微生物营养不良。产生丁酸盐的梭菌簇IV菌株Pulticicoccus pullicaecorum 25-3（T）就是这种候选药物。关于其在结肠微生物群中的丰度及其成虫特性知之甚少。我们使用了M-SHIME（®）（一种用于人类肠道微生物生态系统的体外模拟器）来研究补充单剂量的B. Pullicaecorum 25-3（T）对内腔和粘液相关的8个微生物群的影响个人。与管腔菌群相比，粘液菌群中的B. Pullicaecorum更为丰富。补充单剂量的B. Pullicaecorum 25-3（T）会导致所有个体内腔中的B. Pullicaecorum细菌暂时增加。在两种情况下，与对照组相比，响应者的丁酸盐产量增加。 16S rRNA基因扩增子测序显示响应者的微生物群与无响应者的微生物群不同。我们可以得出结论，B。Pullicaecorum 25-3（T）是一种与粘液相关的细菌，其刺激丁酸盐生产的能力的特点是，在接受微生物群落的组成方面存在很大的个体差异。

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