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首页> 外文OA文献 >UK–Russia Researcher Links Workshop: extracellular vesicles – mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1–5 March 2015
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UK–Russia Researcher Links Workshop: extracellular vesicles – mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1–5 March 2015

机译：英国-俄罗斯研究员链接研讨会：细胞外囊泡-生物发生机理及其在疾病发病机理中的作用罗蒙诺索夫莫斯科国立大学，俄罗斯莫斯科，2015年3月1日至5日

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The UK–Russia extracellular vesicles (EVs) workshop was held at the Medical Center of the M.V. Lomonosov Moscow State University, Moscow, Russia, with 56 attendees from UK and Russian universities and research institutes. The program consisted of 6 research sessions and was focused on studies of EVs isolated from in vitro model systems or biological fluids, including blood and urine. The multidisciplinary program included presentations on mechanisms of EV biogenesis, the role of EVs in disease pathogenesis, the diagnostic value of EVs, including their quantitation and cargo load, as well as the clinical use of EVs in regenerative medicine. Methodological challenges imposed by the nanoscale size of EVs as well as targeted delivery approaches for therapeutics were considered in a separate session on technologies. The main aim of the workshop was to overview challenges confronting EV researchers and to facilitate knowledge exchange between researchers with different backgrounds and skills. Given the lack of definitive EV nomenclature, specific terms (exosomes or microvesicles) were only applied in the meeting report to studies that carried out full EV characterization, including differential ultracentrifugation isolation approaches, comprehensive protein marker characterization, and single vesicle analysis (electron microscopy and nanoparticle analysis), to ascertain EV size and morphology following the International Society for Extracellular Vesicles standardization recommendations (1,2). In studies where characterization was not conclusive, the term EV is used.
机译：英俄细胞外囊泡（EVs）研讨会在M.V.的医学中心举行。俄罗斯莫斯科罗蒙诺索夫国立莫斯科大学，来自英国和俄罗斯的大学和研究所的56名与会者。该计划包括6个研究会议，重点研究从体外模型系统或包括血液和尿液在内的生物体液中分离出的电动汽车。该多学科计划包括关于电动汽车生物发生机理，电动汽车在疾病发病机理中的作用，电动汽车的诊断价值（包括其定量和载货量）以及电动汽车在再生医学中的临床应用的演讲。在单独的技术会议上考虑了电动汽车的纳米级尺寸以及靶向治疗方法所带来的方法学挑战。研讨会的主要目的是概述电动汽车研究人员面临的挑战，并促进具有不同背景和技能的研究人员之间的知识交流。鉴于缺乏明确的EV命名法，会议报告中仅将特定术语（外泌体或微囊泡）应用于进行完整EV表征的研究，包括差异超速离心分离方法，全面的蛋白质标记物表征和单囊泡分析（电子显微镜和纳米颗粒分析），以根据国际细胞外囊泡标准化建议（1,2）确定EV的大小和形态。在表征不是确定性的研究中，使用术语EV。

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