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Comparison of Interproton Distances in DNA Models with Nuclear Overhauser Enhancement Data

机译：DNA模型中带有核过载效应增强数据的质子间距的比较

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摘要

The conformational flexibility inherent in the polynucleotide chain plays an important role in deciding its three-dimensonal structure and enables it to undergo structural transitions in order to fulfil all its functions. Following certain stereochemical guidelines, both right and left handed double-helical models have been built in our laboratory and they are in reasonably good agreement with the fibre patterns for various polymorphous forms of DNA. Recently, nuclear magnetic resonance spectroscopy has become an important technique for studying the solution conformation and polymorphism of nucleic acids. Several workers have used 1H nuclear magnetic resonance nuclear Overhauser enhancement measurements to estimate the interproton distances for the various DNA oligomers and compared them with the interproton distances for particular models of A and Β form DNA. In some cases the solution conformation does not seem to fit either of these models. We have been studying various models for DNA with a view to exploring the full conformational space allowed for nucleic acid polymers. In this paper, the interproton distances calculated for the different stereochemically feasible models of DNA are presented and they are compared and correlated against those obtained from 1Η nuclear magnetic resonance nuclear Overhauser enhancement measurements of various nucleic acid oligomers.
机译：多核苷酸链固有的构象柔韧性在决定其三维结构中起着重要作用，并使它能够进行结构转变以实现其所有功能。遵循某些立体化学指导，我们的实验室已建立了右手和左手双螺旋模型，并且它们与各种多态性形式的DNA的纤维图谱相当吻合。近年来，核磁共振波谱学已经成为研究核酸的溶液构象和多态性的重要技术。一些工作人员使用1H核磁共振Overhauser核增强测量来估计各种DNA低聚物的质子距离，并将它们与A和Β形式DNA特定模型的质子距离进行比较。在某些情况下，解决方案构象似乎不适合这两个模型。我们一直在研究DNA的各种模型，以探索核酸聚合物所允许的完整构象空间。在本文中，介绍了为不同的立体化学可行的DNA模型计算的质子间距，并将其与从1H核磁共振核Overhauser增强测量各种核酸低聚物获得的质子间距进行比较和关联。

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    Gopalakrishnan B; Bansal M;

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  • 年度 1985
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