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PEDOT:PSS interfaces support the development of neuronal synaptic networks with reduced neuroglia response in vitro

机译：PEDOT：PSS接口支持神经突触网络的发展，在体外具有减少的神经胶质细胞反应

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The design of electrodes based on conductive polymers in brain-machine interface technology offers the opportunity to exploit variably manufactured materials to reduce gliosis, indeed the most common brain response to chronically implanted neural electrodes. In fact, the use of conductive polymers, finely tailored in their physical-chemical properties, might result in electrodes with improved adaptability to the brain tissue and increased charge-transfer efficiency. Here we interfaced poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) doped with different amounts of ethylene glycol (EG) with rat hippocampal primary cultures grown for 3 weeks on these synthetic substrates. We used immunofluorescence and scanning electron microscopy combined to single cell electrophysiology to assess the biocompatibility of PEDOT:PSS in terms of neuronal growth and synapse formation. We investigated neuronal morphology, density and electrical activity. We reported the novel observation that opposite to neurons, glial cell density was progressively reduced, hinting at the ability of this material to down regulate glial reaction. Thus PEDOT:PSS is an attractive candidate for the design of new implantable electrodes, controlling the extent of glial reactivity without affecting neuronal viability and function.
机译：在脑机接口技术中基于导电聚合物的电极设计提供了利用可变制造的材料减少神经胶质瘤的机会，神经胶质瘤实际上是对慢性植入神经电极最常见的大脑反应。实际上，对导电聚合物的物理化学性质进行了精心设计，可以使电极对脑组织的适应性得到改善，并提高电荷转移效率。在这里，我们将掺有不同量的乙二醇（EG）的聚（3,4-乙撑二氧噻吩）：聚（苯乙烯磺酸盐）（PEDOT：PSS）与在这些合成底物上生长3周的大鼠海马原代培养物连接。我们使用免疫荧光和扫描电镜结合单细胞电生理学来评估PEDOT：PSS在神经元生长和突触形成方面的生物相容性。我们研究了神经元的形态，密度和电活动。我们报道了这一新颖的观察结果，与神经元相反，神经胶质细胞密度逐渐降低，提示该物质下调神经胶质反应的能力。因此，PEDOT：PSS是设计新型可植入电极，控制神经胶质反应性程度而不影响神经元生存能力和功能的有吸引力的候选者。

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