Roles of FGF20 in dopaminergic neurons and Parkinson's disease.

机译：FGF20在多巴胺能神经元和帕金森氏病中的作用。

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

The fibroblast growth factor (FGF) family comprises 22 members with diverse functions in development and metabolism. Fgf20 was originally identified as a new Fgf preferentially expressed in the substantia nigra pars compacta (SNpc). Fgf20, which acts on proximal cells, significantly enhanced the survival of cultured dopaminergic neurons by activating the mitogen-activated protein kinase (MAPK) pathway through Fgf receptor 1c. In the rat model of Parkinson's disease, Fgf20 afforded significant protection against the loss of dopaminergic neurons. The significant correlation of Parkinson's disease with single-nucleotide polymorphisms in FGF20 indicates that the genetic variability of FGF20 can be a Parkinson's disease risk. Neural and embryonic stem (ES) cells have been considered as cell resources for restorative transplantation strategies in Parkinson's disease. Fgf20 promoted the differentiation of these stem cells into dopaminergic neurons, which attenuated neurological symptoms in animal models of Parkinson's disease. These findings indicate the importance of FGF20 for the differentiation and survival of dopaminergic neurons and the etiology and therapy of Parkinson's disease.

机译：成纤维细胞生长因子（FGF）家族包含22个成员，在发育和代谢中具有多种功能。 Fgf20最初被确定为优先在黑质致密性黑质（SNpc）中表达的新Fgf。作用于近端细胞的Fgf20通过激活经由Fgf受体1c的促有丝分裂原激活的蛋白激酶（MAPK）途径，显着提高了培养的多巴胺能神经元的存活率。在帕金森氏病大鼠模型中，Fgf20提供了针对多巴胺能神经元丢失的显着保护作用。帕金森氏病与FGF20中的单核苷酸多态性显着相关，表明FGF20的遗传变异可能是帕金森氏病的风险。神经和胚胎干（ES）细胞已被视为帕金森氏病的修复性移植策略的细胞资源。 Fgf20促进了这些干细胞向多巴胺能神经元的分化，从而减轻了帕金森氏病动物模型中的神经系统症状。这些发现表明FGF20对于多巴胺能神经元的分化和存活以及帕金森氏病的病因和治疗的重要性。

著录项

作者
Itoh Nobuyuki; Ohta Hiroya;
展开▼
作者单位

展开▼
年度 2013
总页数
原文格式 PDF
正文语种 en
中图分类

相似文献

外文文献
中文文献
专利

1. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. [J] . Jankovic J, Chen S, Le WD Progress in Neurobiology: An International Review Journal . 2005,第1a2期

机译：Nurr1在多巴胺能神经元和帕金森氏病发展中的作用。
2. Nerve growth factor increases survival of dopaminergic graft, rescue nigral dopaminergic neurons and restores functional deficits in rat model of Parkinson's disease. [J] . Chaturvedi RK, Shukla S, Seth K, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2006,第1a2期

机译：神经生长因子可增加帕金森氏病大鼠模型中多巴胺能移植物的存活，挽救黑质多巴胺能神经元并恢复功能缺陷。
3. The role of metal ions in dopaminergic neuron degeneration in Parkinsonism and Parkinson's disease [J] . Irmgard Paris, Juan Segura-Aguilar Monatshefte fur Chemie . 2011,第4期

机译：金属离子在Parkinsonism和Parkinson病中的多巴胺能神经元变性中的作用
4. Glial activation plays a major role in angiotensin-induced dopaminergic cell death in the 6-OHDA model of parkinsonism [C] . J. Rodriguez-Pallares, P. Rey, J.A. Parga, European Meeting on Glial Cells in Health and Disease . 2009

机译：胶质激活在血管紧张素诱导的帕金纳毒素模型中在血管紧张素诱导的多巴胺能细胞死亡中发挥着重要作用
5. Molecular mechanisms of PKCdelta in neurotoxin-induced apoptotic death of nigral dopaminergic neurons: Relevance to the pathogenesis of Parkinson's disease. [D] . Yang, Yongjie. 2005

机译：神经毒素诱导的多巴胺能神经元凋亡死亡中PKCdelta的分子机制：与帕金森氏病的发病机制有关。
6. Roles of FGF20 in dopaminergic neurons and Parkinsons disease [O] . Nobuyuki Itoh, Hiroya Ohta 2013

机译：FGF20在多巴胺能神经元和帕金森氏病中的作用
7. Roles of FGF20 in dopaminergic neurons and Parkinson’s disease [O] . Nobuyuki eItoh, Hiroya eOhta 2013

机译：FGF20在多巴胺能神经元和帕金森病中的作用

Roles of FGF20 in dopaminergic neurons and Parkinson's disease.

摘要

著录项

相似文献

相关主题

期刊订阅