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Studies on the Jikei Electro-Dialyzer Report 5. The Changes of the Circulatory System during Electrohemodialysis

机译：Jikei电渗析仪的研究报告5.电渗析过程中循环系统的变化

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摘要

The author carried out a series of animal expe r iments to study influences upon the circulatory system during application of the Jikei Electro-Dialyzer. Six n ormal dogs and eleven bilaterally nephrec t omized dogs were hemodialized for two hours and changes on the electrocardiographic tracings were observed. Two n ephrectomized dogs were utilized to study cardiac outpu t and a normal dog was utilized to study cardiac out-put, pulmonary arterial pressure, pulmonary capillary pressure and right intracardiac pressure by means of the right cardiac catheterization. One normal dog and three nephrectomized dogs were sacrificed imm ediately after hemodialysis to study histopathological changes. The results obtained are summarize d as follows. 1) The changes on the EKG : The prolon g ation of R-R distance and the decrease in hight of R-spike are observed in majority of the cases in both normal and nephrectomized dogs. It is thought that these changes are most likely caused by the changes of the hemodinamics during hemodialysis. However, the changes of the T-wave are almost accorded with the changes of the serum potassium concentration and are considered to be caused by the changes of the serum electrolyte balance. The appearance and disappearance of arrhythmia are o b served to be accompanied by the changes of the serum electrolyte in some instances. However, such hemodinamic factors as increase of the blood flow or the ventricular automaty following application of hemodializer should be considered as a probable cause of the arrhythmia. 2) The right cardiac catheterization : There are no fixed tend e n cy as for the changes of the cardiac output before and after hemodialysis. In some cases it is observed to be increased but in some other cases decreased. A tendency of elevation of pulmonary arterial pressure, pulmonary capillary pressure and right intracardiac pressure are observed in the first 60 minuts of the hemodialysis. 3) Histopathological changes : A s l i ght degree of vascular dilatation and congestion are seep in the liver and spleen. There are po remarkable histological changes in the lungs and kidneys. In conc l usion, I think it is reasonable to say that the performance of hemodialysis with the Jikei Electro-Dialyzer for two hours duration with the blood flow rate of 50cci does not offer any serious changes on the circulatory system.
机译：作者进行了一系列动物实验，以研究在使用Jikei Electro-Dialyzer期间对循环系统的影响。对六只正常犬和十一只双侧肾切除的犬进行了两个小时的血液除血，并观察了心电图描记的变化。两只右肾切除的狗被用来研究心脏输出，而一只正常的狗被用来通过右心导管检查心脏输出，肺动脉压，肺毛细血管压和右心内压。血液透析后立即将一只正常的狗和三只经肾切除的狗杀死，以研究组织病理学变化。所得结果总结如下。 1）心电图的变化：在正常犬和肾切除犬中，大多数情况下都观察到R-R距离的延长和R-spike的高度降低。据认为，这些变化最有可能是由血液透析过程中的血液动力学变化引起的。然而，T波的变化几乎与血清钾浓度的变化一致，并且被认为是由血清电解质平衡的变化引起的。在某些情况下，心律失常的出现和消失可能伴随着血清电解质的变化。但是，在应用止血剂后，诸如血液流量增加或心室自动性增加等血液动力学因素应被视为心律不齐的可能原因。 2）右心导管检查：血液透析前后心输出量的变化没有固定的趋势。在某些情况下，它会增加，但在另一些情况下，会减少。在血液透析的前60分钟内观察到肺动脉压，肺毛细血管压和右心内压升高的趋势。 3）组织病理学改变：肝脏和脾脏中有相当程度的血管扩张和充血。肺和肾脏有明显的组织学改变。综上所述，我认为用Jikei Electro-Dialyzer进行两个小时，血液流速为50cci的血液透析不会对循环系统造成任何严重的变化，这是合理的。

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    三木 信男;

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  • 年度 1960
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  • 正文语种 ja
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