• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >MODULATION OF LOCUS COERULEAR NEURONAL ACTIVITY BY THE CENTRAL NUCLEUS OF THE AMYGDALA
【2h】

MODULATION OF LOCUS COERULEAR NEURONAL ACTIVITY BY THE CENTRAL NUCLEUS OF THE AMYGDALA

机译：杏仁核中央核对粘着力神经元神经活动的调节

页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The limbic and central noradrenergic systems are sensitive to stress and demonstrate pathophysiology in individuals with mood and anxiety disorders. Neurons from the central nucleus of the amygdala (CeA) form synapses onto the dendrites of noradrenergic neurons of the locus coeruleus (LC) in the rostrolateral peri-coerulear area. The CeA-LC pathway is thought to contain GABA and corticotropin-releasing hormone (CRH), both of which have opposing effects on LC activity. The current study further characterized the CeA-LC pathway in vivo by examining extracellular electrophysiological LC activity during electrical and pharmacological manipulation of the CeA in halothane-anesthetized rats.The majority of LC neurons exhibited an excitatory response to electrical CeA stimulation, with a small group of neurons responding with pure inhibition or antidromic activation. Pharmacological activation of the CeA confirmed excitatory responses to electrical stimulation, whereas pharmacological inactivation of the CeA had no effect on LC activity. Excitatory responses to electrical CeA stimulation were partially attenuated following ventricular infusions of the CRH antagonist, D-Phe-CRH, but were completely attenuated following infusions of the excitatory amino acid antagonist, kynurenic acid. Ventricular administration of kynurenic acid during electrical CeA stimulation also revealed an inhibitory period that simultaneously occurs with excitatory responses.This study confirms previous findings suggesting that the CeA partially mediates excitatory responses via CRH. These findings further suggest that there is a glutamatergic component to excitatory responses following activation of the CeA. In addition, these data suggest that upon activation, the CeA provides a simultaneous inhibitory drive to LC neurons.Collectively, these data provide additional support for an excitatory limbic input to neurons of the LC. The present data also suggest that the CeA may selectively modulate LC activity across its projection sites via the simultaneous inhibitory drive from the CeA. Activation of the CeA-LC pathway, particularly during stress responses, may be critical for noradrenergic modulation of cortical and limbic areas involved in attention, emotional learning, and responses to stressful stimuli.
机译：边缘和中枢去甲肾上腺素能系统对压力敏感，并在患有情绪和焦虑症的个体中表现出病理生理学。来自扁桃体中央核（CeA）的神经元形成突触到位于外侧外侧蓝冠区的蓝斑轨迹（LC）的去甲肾上腺能神经元的树突上。 CeA-LC途径被认为含有GABA和促肾上腺皮质激素释放激素（CRH），两者对LC活性都有相反的影响。目前的研究通过在氟烷麻醉的大鼠中对CeA进行电和药理操作期间检查细胞外电生理LC活性，进一步表征了CeA-LC通路在体内。大多数LC神经元对CeA电刺激表现出兴奋性反应，一小部分纯抑制或抗drodromic激活响应的神经元。 CeA的药理活化证实了对电刺激的兴奋性反应，而CeA的药理失活对LC活性没有影响。在脑室中注入CRH拮抗剂D-Phe-CRH后，对CeA电刺激的兴奋反应部分减弱，但在注入兴奋性氨基酸拮抗剂Kynurenic酸后完全减弱。在脑电刺激CeA的过程中通过心室酸给药也揭示了抑制期与兴奋性反应同时发生。这项研究证实了先前的发现表明CeA部分通过CRH介导兴奋性反应。这些发现进一步表明，CeA激活后，兴奋反应有谷氨酸能成分。此外，这些数据表明，激活后，CeA对LC神经元提供了同时的抑制驱动力。集体地，这些数据为LC神经元的兴奋性边缘输入提供了额外的支持。本数据还表明，CeA可以通过同时抑制CeA的驱动，选择性地调节其投射部位的LC活性。 CeA-LC途径的激活，特别是在应激反应过程中，对于涉及注意力，情绪学习和应激刺激反应的皮质和边缘区域的去甲肾上腺素能调节可能至关重要。

著录项

  • 作者

    Ramsooksingh Meera Devi;

  • 作者单位
  • 年度 2008
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
  • 中图分类

相似文献

  • 外文文献
  • 中文文献
  • 专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号