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首页> 外文OA文献 >The Development of Biodegradable Metallic Screws and Suture Anchors for Soft Tissue Fixation in Orthopaedic Surgeryud
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The Development of Biodegradable Metallic Screws and Suture Anchors for Soft Tissue Fixation in Orthopaedic Surgeryud

机译：骨科手术中软组织固定用可生物降解金属螺钉和缝合锚的开发

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Surgical treatment for injuries to soft connective tissues are estimated at about 800,000 cases each year in the US. For these surgical procedures, interference screws or suture anchors are needed. Currently, materials used for the devices are non-degradable metals or bioresorbable polymers. However, these materials do lead to complications. Metallic materials suffer from difficulties encountered during revision surgery and interference with magnetic resonance imaging; whereas, polymeric materials lead to device fracture during implantation, inconsistent degradation rates, and poor osteointegration. udThe overall goal of this dissertation was to explore the use of Mg-based materials as an alternative to the existing materials. Specifically, the studies focused on Mg-based interference screws for ACL reconstruction and suture anchors for rotator cuff repair. First, a Mg-based interference screw was designed and optimized through in-vitro testing and finite element analysis (FEA). At time zero, ACL reconstruction with Mg-based interference screws was found to restore initial joint stability as well as the in-situ load in the ACL close to the levels of the intact. Also, structural properties of the femur-graft-tibia complex (FGTC) with a Mg-based interference screw were comparable as those with a titanium control. In a follow-up study, joint stability and graft function after 12 weeks of healing were found to be comparable to past studies of ACL reconstruction in a goat model using the robotic/UFS testing system. The stiffness and ultimate load of the FGTC at 12 weeks were comparable to those at time zero. These results indicate that Mg-based interference screws allow for proper healing of the graft. udSimilarly, a Mg-based suture anchor was also designed and developed. Using FEA, the thread depth and pitch of the anchor could be optimized. It was then demonstrated that Mg-based suture anchors could achieve superior fixation over commercially available polymer suture anchors as it could provide a higher stiffness and ultimate load. udIn summary, the potential of Mg-based alloys for fixation of soft tissues to bone has been clearly demonstrated. We hope that the current findings would help the development of a novel class of biodegradable metallic implants that would ultimately help patients with improved outcomes.ud
机译：在美国，每年估计约有800,000例外科手术治疗软性结缔组织损伤。对于这些外科手术，需要干涉螺钉或缝合锚钉。当前，用于装置的材料是不可降解的金属或生物可吸收的聚合物。但是，这些材料确实会导致并发症。金属材料在翻修手术中会遇到困难，并且会干扰磁共振成像。然而，聚合材料会导致植入过程中的器械断裂，降解速率不一致以及骨整合不良。 ud本论文的总体目标是探索使用镁基材料替代现有材料。具体而言，研究集中在用于ACL重建的基于镁的干涉螺钉和用于修复肩袖的缝合锚钉上。首先，通过体外测试和有限元分析（FEA）设计并优化了基于Mg的干涉螺钉。在零时，发现使用基于Mg的干涉螺钉进行ACL重建可恢复初始关节稳定性以及ACL中的原位载荷，使其接近完整水平。同样，具有基于Mg的干涉螺钉的股骨-移植物-胫骨复合体（FGTC）的结构性质与具有钛对照的那些相当。在一项后续研究中，发现愈合12周后的关节稳定性和移植物功能与过去使用机器人/ UFS测试系统在山羊模型中进行ACL重建的研究相当。 FGTC在12周时的刚度和极限载荷与零时时的刚度和极限载荷相当。这些结果表明，基于Mg的干涉螺钉可正确修复移植物。 ud同样，还设计和开发了基于Mg的缝合锚钉。使用FEA，可以优化锚钉的螺纹深度和螺距。然后证明了，基于镁的缝合锚钉可以实现优于市售聚合物缝合锚钉的固定，因为它可以提供更高的刚度和最终载荷。 ud总而言之，镁基合金将软组织固定在骨骼上的潜力已得到明确证明。我们希望当前的发现将有助于开发新型的可生物降解的金属植入物，从而最终帮助患者改善预后。

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    Kim Kwang E;

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