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System and Method for Comparison and Training of Mechanical Circulatory Support Devices: A Patient Independent Platform Using the Total Artificial Heart and Donovan Mock Circulation System

机译：机械循环支持设备比较和训练的系统和方法：使用人工心脏和Donovan模拟循环系统的患者独立平台

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Mechanical circulatory support (MCS) is a viable therapy for end stage heart failure. However, despite clinical success, the ability to compare MCS devices in vitro and perform training scenarios is extremely limited. Comparative studies are limited as different devices cannot be interchanged in a patient due to the surgical nature of implant. Further, training and failure scenarios cannot be performed on patients with devices as this would subject a patient to a failure mode. A need exists for a readily available mock system that can perform comparative testing and training scenarios with MCS devices. Previously, our group has fabricated a well characterized mock circulation system consisting of a SynCardia temporary Total Artificial Heart (TAH) and Donovan Mock Circulation tank (DMC tank). Further, utilizing this system with the TAH operating in reduced output mode, a heart failure model was developed. In the present study, three ventricular assist devices (VADs) were independently attached to the heart failure model to compare device performances over a range of preloads and afterloads. In addition, specific clinical scenarios were created with the system to analyze how VAD-displayed waveforms from the system correlate with clinical scenarios. Finally, each VAD was powered off while attached to the heart failure model to compare fluid flow through the VAD in a pump-failure scenario. We demonstrated that this system can successfully be utilized to compare MCS devices (i.e. ventricular assist devices) and for successful training of patients and clinicians.
机译：机械循环支持（MCS）是治疗晚期心力衰竭的可行方法。但是，尽管临床上取得了成功，但是在体外比较MCS设备和执行训练方案的能力却极为有限。由于植入物的手术性质，不同的设备无法在患者体内互换，因此比较研究受到限制。此外，不能在具有设备的患者上执行训练和失败情况，因为这会使患者处于失败模式。需要一种易于使用的模拟系统，该系统可以使用MCS设备执行比较测试和培训方案。以前，我们的团队已经制造出了一个特征鲜明的模拟循环系统，该系统由SynCardia临时全人工心脏（TAH）和Donovan Mock循环罐（DMC罐）组成。此外，通过在TAH以降低的输出模式运行的情况下使用该系统，开发了心力衰竭模型。在本研究中，将三个心室辅助设备（VAD）独立地附加到心力衰竭模型上，以比较在一系列预负荷和后负荷下的设备性能。此外，系统还创建了特定的临床方案，以分析系统中VAD显示的波形与临床方案之间的关系。最后，在连接到心力衰竭模型时关闭每个VAD的电源，以比较在泵出现故障的情况下通过VAD的流体流量。我们证明了该系统可以成功地用于比较MCS设备（即心室辅助设备）并成功培训患者和临床医生。

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    DeCook Katrina Jolene;

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  • 年度 2015
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