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Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode

机译:甲硝唑在DNA修饰的玻碳电极,汞薄膜电极和玻碳电极上的伏安行为比较

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摘要

The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there was a shift in the peak potentials to more negative values when a bare glassy carbon electrode was used compared to the other two. Besides the advantage of using a solid electrode for the reduction of metronidazole, the DNA-modified galssy carbon electrode enables a lower detection limit of 1.0 muM owing to the preconecentration of the drug on the electrode surface, which is not the case for the mercury thin film or bare glassy carbon electrodes.
机译:比较了用于修饰甲硝唑的3种电极的电分析性能:DNA修饰的高碳碳电极,汞薄膜电极和玻璃碳电极。尽管当使用裸露的玻碳电极时峰值电势会移至更多的负值,但所有三个电极在甲硝唑的还原机理,酸和中性区的pH依赖剂以及碱性介质中的还原机理上都表现出相似的趋势。与其他两个相比。除了使用固体电极还原甲硝唑的优势外,由于药物在电极表面的预富集,DNA修饰的高碳碳电极还可以实现1.0μM的较低检测限,而汞稀的情况并非如此薄膜或裸露的玻璃碳电极。

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