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Targeted Copper Radioisotopes for Nuclear Medicine : Production of 64Cu from natNi by Cyclotron and 67Cu by Reactor

机译:用于核医学的靶向铜放射性同位素:回旋加速器从natNi生产64Cu和反应堆从67Cu生产

摘要

The Copper is one of the most important trace elements in the biosphere. Its importance in blood system and chelate bonds to the bioactive macro-peptides are well known. The nuclear medical applications of Copper radioisotopes such as 64Cu also have wide literature. The 67Cu became the target of the scientific interest due to the optimal nuclear properties for nuclear medicine. The optimal production of these isotopes in quality of high specific activity is different. For production of 64Cu it is more preferable to apply the 64Ni(p,n)64Cu nuclear reaction by cyclotron. The production of 67Cu is possible using the 67Zn(n,p)67Cu nuclear reaction by nuclear reactor. Theoretically the 64Ni(,p)67Cu and 64Ni(7Li,)67Cu are also useable to produce the 67Cu, but the Atomki’s cyclotron isn’t dedicated for that reactions. However for that two radioisotopes have two different production routes, both radioisotopes can be separated by the same chemical method.udThe strength of complexation of metal ions with chloride ions depends of the concentration of chloride ion. This is the theoretical background for separation of different transition metal ions by ion-chromatography [3]ud
机译:铜是生物圈中最重要的微量元素之一。其在血液系统中的重要性以及与生物活性大肽的螯合键是众所周知的。铜放射性同位素如64Cu的核医学应用也有广泛的文献。 67Cu由于具有核医学的最佳核特性而成为科学兴趣的目标。这些同位素在高比活度方面的最佳产量不同。为了生产64Cu,更优选通过回旋加速器进行64Ni(p,n)64Cu核反应。通过核反应堆的67Zn(n,p)67Cu核反应可以生产67Cu。从理论上讲,也可以使用64Ni(),p)67Cu和64Ni(7Li,to)67Cu生产67Cu,但是Atomki的回旋加速器并不专门用于这种反应。但是,由于两种放射性同位素具有两种不同的生产路线,因此可以通过相同的化学方法分离两种放射性同位素。 ud金属离子与氯离子的络合强度取决于氯离子的浓度。这是通过离子色谱法分离不同过渡金属离子的理论背景[3] ud

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    Szűcs Zoltán; Dóczi Rita;

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  • 年度 2014
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