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首页> 外文OA文献 >Fumaric acid monoethyl ester-functionalized poly(D,L-Lactide)/N-vinyl-2- pyrrolidone Resins for the preparation of tissue engineering scaffolds by stereolithography
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Fumaric acid monoethyl ester-functionalized poly(D,L-Lactide)/N-vinyl-2- pyrrolidone Resins for the preparation of tissue engineering scaffolds by stereolithography

机译：富马酸单乙酯官能化聚（D，L-丙交酯）/ N-乙烯基-2-吡咯烷酮树脂的立体光刻法制备组织工程支架

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摘要

Polymer networks were prepared by photocross-linking fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(D,L-lactide) oligomers using Af-vinyl-2-pyrrolidone (NVP) as diluent and comonomer. The use of NVP together with FAME-functionalized oligomers resulted in copolymerization at high rates, and networks with gel contents in excess of 90 were obtained. The hydrophilicity of the poly(D,L-lactide) networks increases with increasing amounts of NVP, networks containing 50 wt of NVP absorbed 40 of water. As the amount of NVP was increased from 30 to 50 wt , the Young's modulus after equilibration in water decreased from 0.8 to 0.2 GPa, as opposed to an increase from 1.5 to 2.1 GPa in the dry state. Mouse preosteoblasts readily adhered and spread onto all prepared networks. Using stereolithography, porous structures with a well-defined gyroid architecture were prepared from these novel materials. This allows the preparation of tissue engineering scaffolds with optimized pore architecture and tunable material properties.
机译：通过使用Af-乙烯基-2-吡咯烷酮（NVP）作为稀释剂和共聚单体，通过光交联富马酸单乙酯（FAME）功能化的三臂聚（D，L-丙交酯）低聚物来制备聚合物网络。 NVP与FAME官能化的低聚物一起使用可导致高速率共聚，并获得凝胶含量超过90的网络。聚（D，L-丙交酯）网络的亲水性随NVP含量的增加而增加，其中NVP含量为50 wt％的网络吸收了40的水。随着NVP的量从30 wt％增加到50 wt％，在水中平衡后的杨氏模量从0.8 GPa降低到0.2 GPa，而在干燥状态下则从1.5 GPa增加到2.1 GPa。小鼠成骨细胞易于粘附并扩散到所有准备好的网络上。使用立体平版印刷术，从这些新颖的材料制备了具有明确的螺旋结构的多孔结构。这允许制备具有优化的孔结构和可调节的材料特性的组织工程支架。

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