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首页> 外文OA文献 >A Screening strategy for selection of Anti-HIV-1 Integrase and anti-HIV-1 Protease Inhibitors from extracts of Indian Medicinal plants
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A Screening strategy for selection of Anti-HIV-1 Integrase and anti-HIV-1 Protease Inhibitors from extracts of Indian Medicinal plants

机译：从印度药用植物提取物中选择抗HIV-1整合酶和抗HIV-1蛋白酶抑制剂的筛选策略

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摘要

Ethanolic and water extracts from six species of Indian medicinal plants mainly distributed in the region of Western Ghats, India such as Morinda citrifolia (leaf), Garcinia indica (leaf), Garcinia cambogia (leaf), Salaciaudoblonga (leaf), Coccinium fenestratum (stem bark) and Calophyllum inophyllum (bark) were tested for their inhibitory activities against two prime enzymes of HIV which are HIV-1 protease (HIV-PR) and HIV-1 integraseud(HIV-IN). The results revealed that the ethanolic and water extract of the bark extract of Calophyllum inophyllum exhibited potent anti-HIV-IN activity with IC50 values of 9.8 and 5.6 μg/ml, respectively. Whereas thoseudfor anti-HIV-1 PR effect were found to be 63.8 and 16.3 μg/ml, respectively. This result strongly supports the basis for the use of C. inophyllum for AIDSudtreatment by local traditional practitioners of Ayurveda and Unani system of Indian medicine and it is the first report on HIV-1 Protease and HIV-1 Integrase enzyme inhibition by this plant extract.
机译：六种印度药用植物的乙醇提取物和水提取物，主要分布在印度西高止山脉地区，如巴戟天（叶子），Gar藤（叶子），藤黄果（叶子），S藜（udo），ene兰测试（树皮）和茶树（Calphyllum inophyllum）（树皮）对HIV的两种主要酶的抑制活性，所述两种主要酶是HIV-1蛋白酶（HIV-PR）和HIV-1整合酶（HIV-IN）。结果显示，茶树皮的树皮提取物的乙醇提取物和水提取物表现出有效的抗HIV-IN活性，IC50值分别为9.8和5.6μg/ ml。而抗HIV-1 PR的作用分别为63.8和16.3μg/ ml。该结果有力地支持了印度阿育吠陀和印度人Unani系统的当地传统从业者利用茶树C. inophyllum进行AIDS 治疗，这是该植物抑制HIV-1蛋白酶和HIV-1整合酶的首次报道。提取。

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