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Synthesis of hollow vaterite CaCO(3) microspheres in supercritical carbon dioxide medium

机译:超临界二氧化碳介质中空心球霰石CaCO(3)微球的合成

摘要

We here describe a rapid method for synthesizing hollow core, porous crystalline calcium carbonate microspheres composed of vaterite using supercritical carbon dioxide in aqueous media, without surfactants. We show that the reaction in alkaline media rapidly conducts to the formation of microspheres with an average diameter of 5 mu m. SEM, TEM and AFM observations reveal that the microspheres have a hollow core of around 0.7 mu m width and are composed of nanograins with an average diameter of 40 nm. These nanograins are responsible for the high specific surface area of 16 m(2) g(-1) deduced from nitrogen absorption/desorption isotherms, which moreover confers an important porosity to the microspheres. We believe this work may pave the way for the elaboration of a biomaterial with a large potential for therapeutic as well as diagnostic applications.
机译:我们在此描述了一种在不使用表面活性剂的情况下,使用超临界二氧化碳在水性介质中合成由球ate石组成的空心,多孔晶体碳酸钙微球的快速方法。我们表明,在碱性介质中的反应迅速进行,以形成平均直径为5微米的微球。 SEM,TEM和AFM观察表明,微球具有约0.7微米宽度的中空核,并且由平均直径为40 nm的纳米颗粒组成。这些纳米颗粒负责从氮吸收/解吸等温线推导的16 m(2)g(-1)的高比表面积,而且赋予微球重要的孔隙率。我们相信这项工作可能为生物材料的开发铺平道路,该材料具有巨大的治疗和诊断应用潜力。

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