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miRBase Tracker : keeping track of microRNA annotation changes

机译：miRBase Tracker：跟踪microRNa注释的变化

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摘要

Since 2002, information on individual microRNAs (miRNAs), such as reference names and sequences, has been stored in miRBase, the reference database for miRNA annota- tion. As a result of progressive insights into the miRNome and its complexity, miRBase underwent addition and deletion of miRNA records, changes in annotated miRNA se- quences and adoption of more complex naming schemes over time. Unfortunately, miRBase does not allow straightforward assessment of these ongoing miRNA annota- tion changes, which has resulted in substantial ambiguity regarding miRNA identity and sequence in public literature, in target prediction databases and in content on various commercially available analytical platforms. As a result, correct interpretation, compari- son and integration of miRNA study results are compromised, which we demonstrate here by assessing the impact of ignoring sequence annotation changes. To address this problem, we developed miRBase Tracker (www.mirbasetracker.org), an easy-to-use on- line database that keeps track of all historical and current miRNA annotation present in the miRBase database. Three basic functionalities allow researchers to keep their miRNA annotation up-to-date, reannotate analytical miRNA platforms and link published results with outdated annotation to the latest miRBase release. We expect miRBase Tracker to increase the transparency and annotation accuracy in the field of miRNA research. Database URL: www.mirbasetracker.org

机译：自2002年以来，有关单个microRNA（miRNA）的信息（例如参考名称和序列）已存储在miRBase（miRNA注释的参考数据库）中。随着对miRNome及其复杂性的深入了解，miRBase经历了miRNA记录的添加和删除，注释的miRNA序列的变化以及随着时间的推移采用了更复杂的命名方案。不幸的是，miRBase不允许直接评估这些正在进行的miRNA注释变化，这导致在公共文献，靶标预测数据库以及各种市售分析平台上的内容中，有关miRNA身份和序列的认识很模糊。结果，miRNA研究结果的正确解释，比较和整合受到损害，我们在这里通过评估忽略序列注释变化的影响来证明这一点。为了解决这个问题，我们开发了miRBase Tracker（www.mirbasetracker.org），这是一种易于使用的在线数据库，可以跟踪miRBase数据库中存在的所有历史和当前miRNA注释。三种基本功能使研究人员可以保持其miRNA注释的最新状态，重新注释分析性miRNA平台，并将已发布的结果与过时的注释链接到最新的miRBase版本。我们希望miRBase Tracker能够提高miRNA研究领域的透明度和注释准确性。数据库URL：www.mirbasetracker.org

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Van Peer Gert; Lefever Steve; Anckaert Jasper; Beckers Anneleen; Rihani Ali; Van Goethem Alan; Volders Pieter-Jan; Zeka Fjoralba; Ongenaert Maté; Mestdagh Pieter; Vandesompele Jo;
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1. miRBase Tracker: keeping track of microRNA annotation changes [J] . Alan Van Goethem, Ali Rihani, Anneleen Beckers, Database . 2014,第1期

机译：miRBase Tracker：跟踪microRNA注释变化
2. miRBase: integrating microRNA annotation and deep-sequencing data [J] . Ana Kozomara, Sam Griffiths-Jones Nucleic acids research . 2011,第suppla1期

机译：miRBase：整合microRNA注释和深度测序数据
3. Keeping track: Leading vehicle tracking systems company Tracker explains the benefits of it radio- and satellite-based tracking systems [J] . Matthew J. Bailey Materials Handling News . 2004,第554期

机译：保持跟踪：领先的车辆跟踪系统公司Tracker解释了其基于无线电和卫星的跟踪系统的优势
4. Nanoparticles for simultaneous cell tracking and microRNA delivery [C] . Renata S.M. Gomes, Ricardo Neves, Lowri Cochlin, World biomaterials congress . 2012

机译：纳米粒子可同时进行细胞跟踪和microRNA输送
5. Consensus seeking, formation keeping, and trajectory tracking in multiple vehicle cooperative control. [D] . Ren, Wei. 2004

机译：多车协同控制中的共识搜寻，编队保持和轨迹跟踪。
6. miRBase Tracker: keeping track of microRNA annotation changes [O] . Gert Van Peer, Steve Lefever, Jasper Anckaert, 2014

机译：miRBase Tracker：跟踪microRNA注释变化
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