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Early changes of auditory brain stem evoked response after radiotherapy for nasopharyngeal carcinoma - A prospective study

机译:鼻咽癌放疗后听觉脑干诱发反应的早期变化 - 一项前瞻性研究

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摘要

A prospective study of the effect of radiotherapy for nasopharyngeal carcinoma on hearing was carried out on 49 patients who had pure tone, impedance audiometry and auditory brain stem evoked response (ABR) recordings before, immediately, three, six and 12 months after radiotherapy. Fourteen patients complained of intermittent tinnitus after radiotherapy. We found that 11 initially normal ears of nine patients developed a middle ear effusion, three to six months after radiotherapy. There was mixed sensorineural and conductive hearing impairment after radiotherapy. Persistent impairment of ABR was detected immediately after completion of radiotherapy. The waves I-III and I-V interpeak latency intervals were significantly prolonged one year after radiotherapy. The study shows that radiotherapy for nasopharyngeal carcinoma impairs hearing by acting on the middle ear, the cochlea and the brain stem auditory pathway.
机译:对鼻咽癌放疗对听力的影响进行了一项前瞻性研究,研究对象是49名在放疗前,治疗后,治疗后立即,治疗后,治疗后三个月,六个月和十二个月均具有纯音,阻抗测听和听性脑干诱发反应(ABR)录音的患者。十四名患者在放疗后主诉间歇性耳鸣。我们发现,放疗后三至六个月,有9位患者的11头正常耳朵出现了中耳积液。放疗后出现混合的感觉神经和传导性听力障碍。放疗完成后立即检测到永久性ABR损伤。放疗后一年,I-III波和I-V波峰间潜伏期明显延长。研究表明,鼻咽癌的放射疗法通过作用于中耳,耳蜗和脑干听觉通路而损害听力。

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