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Compositions and methods for affecting movement of contaminants, bodily fluids or other entities, and/or affecting other physiological conditions

机译：用于影响污染物，体液或其他实体的运动和/或影响其他生理条件的组合物和方法

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Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatment such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination with an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.
机译：配制在生理条件下自组装的组合物以用于伤口。该制剂包括药学上可接受的载体或作为医疗装置或涂层的一部分提供。所述制剂还可包含其他治疗剂，预防剂或诊断剂。可以适当地施用所述制剂以治疗一种或多种疾病或病症。例如，该制剂可用于修复损伤或在肺，眼或硬脑膜的手术过程中，或在硬膜外或脊髓轻拍后，以阻止血液，间质液或脑脊髓液的泄漏。所述制剂可以施用至烧伤或溃疡。可以将制剂分散在缝合线或粘合剂中，以在伤口缝合或胶合时或在伤口缝合或胶合后释放时施用，从而限制出血，组织液或其他诸如实质性组织如肝脏产生的液的流失，胰腺和胃肠道。该制剂可以在绷带，纱布，海绵或其他材料中的任何出血部位使用，以立即控制出血，或者如果最初的治疗（例如缝合或压力不足）释放，则可以稍后释放以控制出血。在一个实施方案中，该制剂以干燥或冻干的粉末形式提供。在另一个实施方案中，该材料在水中提供。在另一个实施方案中，该材料与油组合提供并形成层压体。在另一个实施方案中，将制剂作为涂层提供在装置例如支架或导管上。该材料也可用于分离组织，保存组织以用于随后的移植或重新附着以及用作填充剂，稳定剂或水合剂。

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