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>Povezanost koncentracije urične kiseline u serumu i ishoda sustavnog trombolitičkog liječenja akutnog infarkta mozga alteplazom Correlation of serum uric acid level and the efficacy of systemic thrombolyses with alteplase in acute ischemic stroke
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Povezanost koncentracije urične kiseline u serumu i ishoda sustavnog trombolitičkog liječenja akutnog infarkta mozga alteplazom Correlation of serum uric acid level and the efficacy of systemic thrombolyses with alteplase in acute ischemic stroke
A large number of epidemiological studies reported controverse association between elevated serum levels of uric acid and stroke outcome. Results of some studies show link between increasing serum urate level and worse outcome and risk of early clinical deterioration after acute stroke. Others report a protective, antioxidant role of uric acid that inffluence positively on recanalization succes and reduce infarct volume size, and thus better clinical recovery. Following clinical outcome of our thrombolised patients with defined levels of serum uric acid in 24 hours after stroke onset period, we didn't find worse outcome in those with elevated serum uric acid. Patients with higher uric acid levels had higher sistolic an dyastolic blood pressure at admission, and lower NIHSS score. Significant lower proportion of intracerebral bleeding occured in patients with higher uric acid levels, and we defined cut off value as 256 μmol/L. Patients with higher uric acid level had atrial flutter more frequently than others. Our results are consistent with the results of possible neuroprotective role of uric acid in patients with stroke treated with thrombolytic therapy.
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