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The prognosis of patients with coronary artery disease complicated by postload hyperinsulinemia

机译：The prognosis of patients with coronary artery disease complicated by postload hyperinsulinemia

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Background: The long-term prognosis of coronary artery disease (CAD) patients with insulin resistance has not been fully examined. In this study, we investigated the influence of postload hyperinsulinemia (PHI) after a 75-g oral glucose tolerance test (OGTT), on the long-term prognosis of CAD patients. Methods: All study patients were diagnosed as having CAD by coronary angiography. The OGTT was performed for all patients to establish their blood glucose. Measurement of serum insulin was also performed simultaneously. Patients with 2-h insulin level of ≥. 64. mU/l after the OGTT were included in the postload hyperinsulinemia (PHI) group, and the others were included in the non-PHI group. The prognosis of 208 patients (96 from the PHI group and 112 from the non-PHI group) was retrospectively investigated. Study end points were the composite of death from any cause, unexpected hospitalization for heart failure, new-onset ACS, angina pectoris requiring PCI or CABG, cerebrovascular disease (CVD), and peripheral artery disease (PAD). Variables were compared using Kaplan-Meier analysis and the log-rank tests. Results: The mean follow-up period was 78.7. months. Cardiovascular events including death were 40.6% in the PHI group and 23.2% in the non-PHI group (log-rank p = 0.0144). CVD, PCI, and CABG occurred continuously from early to late stage of follow-up in the PHI group compared with the non-PHI group. Conclusions: The present study showed that the prognosis of CHD patients with PHI was poor. Thus, it is important to pay attention to these conditions for improving the prognosis of CAD patients.
机译：背景：胰岛素抵抗的冠状动脉疾病（CAD）患者的长期预后尚未得到充分检查。在这项研究中，我们调查了75克口服葡萄糖耐量测试（OGTT）后负荷后高胰岛素血症（PHI）对CAD患者长期预后的影响。方法：所有研究患者均经冠状动脉造影诊断为CAD。对所有患者进行OGTT以确定其血糖。血清胰岛素的测定也同时进行。 2小时胰岛素水平≥的患者。 64. OGTT后的mU / l包括在负荷后高胰岛素血症（PHI）组中，其他则包括在非PHI组中。回顾性分析了208例患者的预后（PHI组96例，非PHI组112例）。研究终点是任何原因导致的死亡，因心力衰竭而意外住院，新发ACS，需要PCI或CABG的心绞痛，脑血管疾病（CVD）和外周动脉疾病（PAD）的综合。使用Kaplan-Meier分析和对数秩检验比较变量。结果：平均随访期为78.7。个月。包括死亡在内的心血管事件在PHI组中为40.6％，在非PHI组中为23.2％（log-rank p = 0.0144）。与非PHI组相比，PHI组从随访的早期到晚期连续发生CVD，PCI和CABG。结论：本研究表明，CHD合并PHI的患者预后较差。因此，重要的是要注意这些条件以改善CAD患者的预后。

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