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首页> 外文OA文献 >Efficacy of targeted versus non-targeted exercise and behavioural interventions onudfatigue in multiple sclerosis: systematic review and meta-analysis
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Efficacy of targeted versus non-targeted exercise and behavioural interventions onudfatigue in multiple sclerosis: systematic review and meta-analysis

机译：有针对性的与非针对性的运动和行为干预的效果多发性硬化症的疲劳：系统评价和荟萃分析

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Review question(s)udThe specific objectives are to:ud(1) Provide a narrative synthesis of all the interventions, including a summary of the nature of the intervention usingudthe Template for intervention Description and Replication (TiDieR), and assessment of study quality (risk of bias),udalongside the standardised intervention effect sizes. As a detailed synthesis already includes studies evaluatingudinterventions specifically targeting MS fatigue (ref: CRD42016033763), the narrative synthesis will focus on studiesudevaluating interventions that (a) do not specifically target fatigue, or (b) measured fatigue as a secondary outcome.ud(2) Conduct (pair-wise) meta-analyses to pool effect sizes across intervention types (exercise, behavioural, mixed)udand estimate statistical heterogeneity.ud(3) Directly compare specific types of targeted versus non-targeted exercise, behavioural and combined interventionsudon fatigue in multiple sclerosis, using network meta-analyses.ud(4) Conduct exploratory moderator and sensitivity analyses to explore how treatment effects vary according to healthudcare professional (HCP) contact, type of MS, and study quality (i.e. risk of bias).

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