首页>
外国专利>
LA REPROGRAMMATION ÉPIGÉNOMIQUE À GRANDE ÉCHELLE RELIE LE MÉTABOLISME ANABOLIQUE DU GLUCOSE AUX MÉTASTASES À DISTANCE AU COURS DE L'ÉVOLUTION DE LA PROGRESSION DU CANCER DU PANCRÉAS
LA REPROGRAMMATION ÉPIGÉNOMIQUE À GRANDE ÉCHELLE RELIE LE MÉTABOLISME ANABOLIQUE DU GLUCOSE AUX MÉTASTASES À DISTANCE AU COURS DE L'ÉVOLUTION DE LA PROGRESSION DU CANCER DU PANCRÉAS
The present invention relates to a method of identifying targets for epigenetic reprogramming comprising detecting large organized heterochromatin lysine (K)-9 modified domains (LOCKs) and large DNA hypomethylated blocks in a sample containing DNA from a subject having cancer, for example, PDAC. The invention also provides for the use of differentially expressed genes to identify metastatic propensity in primary tumors, wherein the genes are selected from genes in the Tables herein, oxidative stress genes, EMT genes, immunological response genes, DNA repair genes, glucose metabolism genes, oxPPP genes, and PGD genes. Further, the invention provides a method for identifying agents or compounds to affect epigenomic changes, including inhibition of oxPPP comprising analyzing a sample from a subject before and after contacting with the agent or compound and determining the effect of the agent or compound on the epigenomic changes.
展开▼
