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Methods for treating metabolic disorders associated with lipodystrophy and defective insulin production or defective insulin signaling
Methods for treating metabolic disorders associated with lipodystrophy and defective insulin production or defective insulin signaling
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摘要
The present invention relates to metabolic disorders associated with a deficiency in insulin signaling, such as insulin receptor mutation disorder (INSR (INSR)), for FGF21 polypeptide or FGF21 protein, or mutants, variants and fusions thereof, Metabolism associated with deficiency of insulin production such as type 1 diabetes, mixed dyslipidemia, nonalcoholic fatty liver disease (NAFLD), etc.) and / or autoimmune insulin receptor disorder (type B insulin resistance) New treatments for treating diverse lipodystrophies such as sexual diseases and other metabolic disorders and HIV / HAART-induced partial lipodystrophy and reducing mortality and morbidity in critically ill patients To identification.
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