首页>
外国专利>
SYSTEMS-LEVEL ANALYSIS OF 32 TCGA CANCERS REVEALS DISEASE-DEPENDENT TRNA FRAGMENTATION PATTERNS AND VERY SELECTIVE ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT ELEMENTS
SYSTEMS-LEVEL ANALYSIS OF 32 TCGA CANCERS REVEALS DISEASE-DEPENDENT TRNA FRAGMENTATION PATTERNS AND VERY SELECTIVE ASSOCIATIONS WITH MESSENGER RNAS AND REPEAT ELEMENTS
Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
展开▼
