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STRAIN OF BACTERIA SALMONELLA ENTERICA SUBSPECIES ENTERICA SEROVAR TYPHI B-8453 WITH LOW LEVEL RESISTANCE TO FLUOROQUINOLONES, USED AS A CONTROL STRAIN FOR PHENOTYPIC AND MOLECULAR STUDIES IN DIAGNOSING TYPHOID FEVER
STRAIN OF BACTERIA SALMONELLA ENTERICA SUBSPECIES ENTERICA SEROVAR TYPHI B-8453 WITH LOW LEVEL RESISTANCE TO FLUOROQUINOLONES, USED AS A CONTROL STRAIN FOR PHENOTYPIC AND MOLECULAR STUDIES IN DIAGNOSING TYPHOID FEVER
FIELD: microbiology.;SUBSTANCE: invention relates to bacteriology. Disclosed is a strain of Salmonella enterica sbsp. enterica serovar Typhi B-8453, characterized by low level resistance to fluoroquinolones caused by a mutation in chromosomal gene gyrA of Ser83Tyr type. Presented strain is deposited in the State collection of pathogenic microorganisms and cell cultures "GKPM-Obolensk" under registration number B-8453. Strain can be used as a control strain for phenotypic (detection of resistance of low level to fluoroquinolones) and molecular (detection of a mutation in gene gyrA of Ser83Tyr type) of researches at diagnostics of typhoid fever.;EFFECT: disclosed is a strain of bacteria Calmonella enterica subspecies enterica serovar Typhi B-8453 with low level resistance to fluoroquinolones, used as a control strain for phenotypic and molecular studies in diagnosing typhoid fever.;1 cl, 4 ex
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机译：技术领域本发明涉及细菌学。公开了一种肠炎沙门氏菌菌株。鼠伤寒沙门氏菌B-8453，其特征是由于Ser83Tyr型染色体基因gyrA突变引起的对氟喹诺酮类药物的低水平耐药性。所提供的菌株在病原微生物和细胞培养物“ GKPM-Obolensk”的州立集中保藏，注册号为B-8453。该菌株可用作伤寒诊断中研究的表型（检测低水平的氟喹诺酮类耐药性）和分子（检测Ser83Tyr型gyrA基因突变）的对照菌株。细菌小肠沙门氏菌肠型血清型Typhi B-8453，对氟喹诺酮类药物具有低水平的耐药性，用作表型和分子研究的对照菌株，用于诊断伤寒。; 1 cl，4 ex
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