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PLASMINOGEN-SUBSTITUTIVE THERAPY IN PLASMINOGEN DEFICIENCY

机译:纤溶原缺乏症的纤溶原替代治疗

摘要

Subjects of the invention are a method of plasminogen supplementation in a plasminogen-deficient subject, and method for the treatment of plasminogen-deficiency in a plasminogen-deficient subject. These methods comprise administering to the plasminogen-deficient subject a dose of plasminogen, and more particularly Glu-plasminogen, for increasing the subject plasminogen activity level by at least about 1%, and more particularly by at least about 10%, of the normal plasminogen activity and for maintaining said increased plasminogen activity level over a supplementation period or a treatment period. The plasminogen-deficient subject of the present invention may suffer from Type-I, Type-II plasminogen-deficiency or an acquired deficiency.
机译:本发明的主题是在纤溶酶原不足的受试者中补充纤溶酶原的方法,以及在纤溶酶原不足的受试者中治疗纤溶酶原不足的方法。这些方法包括给予纤溶酶原缺陷的受试者一定剂量的纤溶酶原,更特别地是Glu-纤溶酶原,以使受试者的纤溶酶原活性水平增加正常纤溶酶原的至少约1%,并且更特别地至少约10%。在补充期或治疗期中,用于维持所述增加的纤溶酶原活性水平。本发明的纤溶酶原缺陷的受试者可以患有I型,II型纤溶酶原缺陷或获得性缺陷。

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