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GOLGA2 Liver fibrosis mouse model without GOLGA2 gene
GOLGA2 Liver fibrosis mouse model without GOLGA2 gene
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机译:没有GOLGA2基因的GOLGA2肝纤维化小鼠模型
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摘要
The present invention relates to a liver fibrosis mouse model in which the GOLGA2 gene is knocked out, a composition for preparing the liver fibrosis mouse model, a liver fibrosis mouse model preparation method, and a liver fibrosis inhibition or screening method for a therapeutic agent. When the GOLGA2 gene knockout liver fibrosis mouse model according to the present invention is used, there is an advantage that a model in which fibrosis is induced in the entire region of the liver due to genetic mutation without serious lesion of liver tissue can be used. In addition, the model can be used in various ways as a model for the study of the association between abnormal morphology of the Golgi apparatus, autophagy, and liver fibrosis, and can be used as an animal model for screening a therapeutic agent for genetic-based liver fibrosis rather than chemical-based liver fibrosis.
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