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NEP NEP INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ATRIAL ENLARGEMENT OR REMODELING
NEP NEP INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ATRIAL ENLARGEMENT OR REMODELING
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机译:NEP NEP抑制剂,用于治疗因心房扩大或重塑而引起的疾病
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摘要
The present invention is an NEP inhibitor prodrug, N-(3-carboxy-1-oxopropyl)-(4S)-p, for use in the treatment, prevention or delay of progression of a disease characterized by atrial dilatation and/or remodeling. -Phenylphenylmethyl)-4-amino-(2R)-methylbutanoic acid ethyl ester or a pharmaceutically acceptable salt thereof; Or NEP inhibitor N-(3-carboxy-1-oxopropyl)-(4S)-p-phenylphenylmethyl)-4-amino-(2R)-methylbutanoic acid or a pharmaceutically acceptable salt, prodrug thereof; A therapeutically effective amount or a prophylactically effective amount of an NEP inhibitor or a NEP inhibitor prodrug or a pharmaceutically acceptable thereof to a subject in need of treatment, prevention or delay of progression of a disease characterized by atrial dilatation and/or remodeling, such as a human subject. It relates to a method of treating, preventing or delaying progression of a disease characterized by atrial dilatation and/or remodeling, comprising administering a salt, prodrug. The present invention further comprises a NEP inhibitor or a NEP inhibitor prodrug or a pharmaceutically acceptable salt, prodrug thereof for use in the treatment, prevention or delay of progression of a disease characterized by atrial expansion and/or remodeling. It relates to a pharmaceutical composition or a commercial package.
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