首页> 外国专利> COMPOSITION FOR IMMUNOSTAINING OF CLEARED HUGE BIOLOGICAL TISSUE AND IMMUNOSTAINING METHOD FOR CLEARED HUGE TISSUE

COMPOSITION FOR IMMUNOSTAINING OF CLEARED HUGE BIOLOGICAL TISSUE AND IMMUNOSTAINING METHOD FOR CLEARED HUGE TISSUE

机译:清除巨大生物组织的免疫抑制的组合物和清除巨大组织的免疫方法

摘要

Disclosed is a composition for immunostaining of a cleared large tissue and a method of immunostaining of a cleared large living tissue using the same. The composition for immunostaining of the cleared large tissue is improved in the permeation of the antibody, which is an immunostaining problem that the conventional methods have, by improving the antibody permeability deeply in the cleared living tissue, especially in large living tissue with a thickness of 3 mm or more. By overcoming limitations and shortening the time taken for immunostaining of large tissues, it is possible to simply and quickly perform 3D bio imaging with high resolution of large living tissues, and to identify and treat the causes of various diseases through structured images It can be useful to predict the development and effectiveness and toxicity of drugs. Also. It can be used by grafting it to various medical devices, and in particular, it can be used as an in vitro diagnostic device by making it as a kit.
机译:公开了一种用于对清除的大组织进行免疫染色的组合物以及使用该组合物对清除的大活组织进行免疫染色的方法。用于清除的大组织的免疫染色的组合物的抗体渗透性得到改善,这是常规方法通过深深地改善清除的活组织,特别是厚度为2μm的大的活组织中的抗体渗透性而存在的免疫染色问题。 3毫米以上。通过克服局限性并缩短对大型组织进行免疫染色的时间,可以简单,快速地以高分辨率对大型活体组织进行3D生物成像,并通过结构化图像识别和治疗各种疾病的原因。预测药物的开发,效果和毒性。也。可以通过将其移植到各种医疗设备上来使用,特别是通过将其制成套件来用作体外诊断设备。

著录项

  • 公开/公告号KR102141496B1

    专利类型

  • 公开/公告日2020-08-06

    原文格式PDF

  • 申请/专利权人 한국화학연구원;

    申请/专利号KR20180048947

  • 发明设计人 박순현;김기석;

    申请日2018-04-27

  • 分类号G01N1/30;G01N33/483;G01N33/532;G01N33/68;

  • 国家 KR

  • 入库时间 2022-08-21 11:04:02

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