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GENE RECOMBINANT EXPRESSION VECTOR SYSTEM FOR PRODUCING SELF-ASSEMBLED NANOPARTICLES AND METHOD USING SAME
GENE RECOMBINANT EXPRESSION VECTOR SYSTEM FOR PRODUCING SELF-ASSEMBLED NANOPARTICLES AND METHOD USING SAME
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机译：用于生产自组装纳米粒子的基因重组表达载体系统和使用该载体的方法
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摘要
The present invention relates to a self-assembled nanoparticle structure, which uses an N-terminal domain RNA-interaction domain (RID) of a human-derived lysyl-tRNA synthetase at the N-terminus of a target protein as a new fusion partner, and has ferritin bound to the C-terminus; an expression vector capable of producing the same; and a novel use thereof. According to the present invention, it is possible to mass-produce 60 to 110 kDa of an insoluble target protein, which was difficult to generate in water-soluble environment, in water-soluble environment without refolding. The target protein can form self-assembled nanoparticles presented on the surface in an immunologically meaningful structure, and thus can be used as a vaccine to increase immunogenicity and as a diagnostic antigen to diagnose various diseases.;COPYRIGHT KIPO 2020
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